HPLC of Formula: C8H8O2. Recently I am researching about ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; INHIBITORS; BINDING; HYBRIDS, Saw an article supported by the Science and Technology Research Program of Shandong Academy of Medical Sciences [2017-16]; Shandong Provincial Natural Science FoundationNatural Science Foundation of Shandong Province [ZR2018LH021]; Innovation Project of Shandong Academy of Medical Sciences. Published in TAYLOR & FRANCIS LTD in ABINGDON ,Authors: Hu, YH; Yang, J; Zhang, Y; Liu, KC; Liu, T; Sun, J; Wang, XJ. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid
The work is focused on the design of drugs that prevent and treat Alzheimer’s disease (AD) and its complications. A series of 3-(4-aminophenyl)-coumarin derivatives designed, synthesised, fully characterised and evaluated in vitro/vivo. The biological assay experiments showed that some compounds displayed a clearly selective inhibition for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Among all compounds, compound 4m exhibited the highest AChE inhibition with an IC50 value of 0.091 +/- 0.011 mu M and compound 4k exhibited the highest BuChE inhibition with an IC50 value of 0.559 +/- 0.017 mu M. A zebrafish behaviour analyser (Zebrobox) was used to determine the behavioural effects of the active compound on the movement distance of the aluminium chloride-induced zebrafish. Compound 4m offered a potential drug design concept for the development of therapeutic or preventive agents for AD and its complications.
Welcome to talk about 99-04-7, If you have any questions, you can contact Hu, YH; Yang, J; Zhang, Y; Liu, KC; Liu, T; Sun, J; Wang, XJ or send Email.. HPLC of Formula: C8H8O2
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com