An article Synthesis of novel 6,7-dimethoxy-4-anilinoquinolines as potent c-Met inhibitors WOS:000450396900001 published article about HEPATOCYTE GROWTH-FACTOR; KINASE INHIBITORS; TYROSINE KINASE; FACTOR-RECEPTOR; SCATTER-FACTOR; CANCER; DISCOVERY; AMPLIFICATION; RESISTANCE; CARCINOMA in [Zhang, Qing-Wen; Ye, Zi-Dan; Shen, Chang; Tie, Hong-Xia; Wang, Lei; Shi, Lei] China Pharmaceut Univ, Dept Med Chem, Jiangsu Key Lab Drug Design & Optimizat, Nanjing 210009, Jiangsu, Peoples R China in 2019, Cited 31. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2. Safety of 2,6-Difluorobenzoic acid
HGF/c-Met signalling pathway plays an important role in the development of cancers. A series of 6,7-dimethoxy-4-anilinoquinolines possessing benzimidazole moiety were synthesised and identified as potent inhibitors of the tyrosine kinase c-Met. Their in vitro biological activities against three cancer cell lines (A549, MCF-7, and MKN-45) were also evaluated. Most of these compounds exhibited moderate to remarkable potency. Among them, compound 12n showed the most potent inhibitory activity against c-Met with IC50 value of 0.030 +/- 0.008 mu M and it also showed excellent anticancer activity against the tested cancer cell lines at low micromolar concentration. Molecular docking verified the results and revealed the possible binding mode of the most promising compound 12n into the ATP-binding site of c-Met kinase.
Safety of 2,6-Difluorobenzoic acid. Welcome to talk about 385-00-2, If you have any questions, you can contact Zhang, QW; Ye, ZD; Shen, C; Tie, HX; Wang, L; Shi, L or send Email.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com