Zhang, GD; Hu, ZY; Belitz, F; Ou, Y; Pirkl, N; Goossen, LJ in [Zhang, Guodong; Hu, Zhiyong; Belitz, Florian; Ou, Yang; Pirkl, Nico; Goossen, Lukas J.] Ruhr Univ Bochum, Fak Chem & Biochem, Univ Str 150, D-44801 Bochum, Germany published Rhodium-Catalyzed Annelation of Benzoic Acids with ,-Unsaturated Ketones with Cleavage of C-H, CO-OH, and C-C Bonds in 2019.0, Cited 99.0. Application In Synthesis of 3-Methylbenzoic acid. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.
In the presence of a [Cp*RhCl2](2) catalyst, the Lewis acid In(OTf)(3), and the mild base Na2CO3, aromatic carboxylates and ,-unsaturated ketones undergo a unique hydroarylation/Claisen/retro-Claisen process to give the corresponding indanones. In this carboxylate-directed ortho-C-H annelation, the C-COR bond of the ketone and the CO-OH group of the aromatic carboxylate are cleaved, and the hydroxy group is transferred from the aromatic to the aliphatic acyl residue. This reactivity is synthetically useful, particularly when starting from cyclic ketones, which are converted into indanones bearing aliphatic carboxylate side chains, thus greatly increasing the molecular complexity of aromatic carboxylates in a single step.
Application In Synthesis of 3-Methylbenzoic acid. Welcome to talk about 99-04-7, If you have any questions, you can contact Zhang, GD; Hu, ZY; Belitz, F; Ou, Y; Pirkl, N; Goossen, LJ or send Email.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com