An article Antimalarial, antiproliferative, and apoptotic activity of quinoline-chalcone and quinoline-pyrazoline hybrids. A dual action WOS:000489305700020 published article about BETA-HEMATIN FORMATION; IN-VITRO; POTENTIAL ANTIMALARIAL; MOLECULAR-MECHANISM; HEMOZOIN FORMATION; MALARIA; ANTICANCER; QUERCETIN; DERIVATIVES; INHIBITION in [Charris, Jaime E.; Monasterios, Melina C.; Acosta, Maria E.; Rodriguez, Miguel A.; Gamboa, Neira D.] Cent Univ Venezuela, Fac Pharm, Biochem Unit, Organ Synth Lab, Los Chaguaramos 1041-A, Caracas 47206, Venezuela; [Martinez, Gricelis P.; Mijares, Michael R.] Cent Univ Venezuela, Fac Pharm, Biotechnol Unit, Los Chaguaramos 1041-A, Caracas 47206, Venezuela; [Rojas, Hector R.; Mijares, Michael R.; De Sanctis, Juan B.] Cent Univ Venezuela, Fac Med, Inst Immunol, Los Chaguaramos 1050-A, Caracas 50109, Venezuela; [De Sanctis, Juan B.] Palacky Univ, Fac Med, Inst Mol & Translat Med, Hnevotinska 1333-5, Olomouc 77900, Czech Republic in 2019, Cited 62. SDS of cas: 93-02-7. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7
A series of quinoline-chalcone (E)-1-[3 or 4-(7-chloroquinolin-4-ylamino) phenyl]-3-(phenyl substituted) prop-2-ene-1-one (4, 5), and quinoline-pyrazoline hybrids 7-Chloro-N-[3 or 4-(4,5-dihydro-5-(phenyl-substituted)-1H-pyrazol-3-yl] phenyl) quinoline-4-amine (6, 7) were synthesized with the aim of achieving an antimalarial and anticancer dual action. Most of the compounds showed significant inhibition (%>80) of beta-hematin formation. The existing structures were tested in vivo as potential antimalarials in mice infected with P. berghei ANKA, chloroquine susceptible strain. Some of the compounds exhibited antimalarial activity comparable to that of chloroquine. Moreover, the compounds induce cell death on two human cancer cell lines (Jurkat E6.1 and HL60) without affecting the primary culture of human lymphocytes. Flow cytometry analysis confirmed the increase in apoptotic cell death after 24 h. Based on the structural analysis, these quinoline hybrids represent new compounds potentially useful for malaria end leukemia treatments.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com