I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Design, synthesis, and biological evaluation of novel pyrrolo[1,2-a]pyrazine derivatives published in 2019.0. Category: isothiazole, Reprint Addresses Kim, I (corresponding author), Yonsei Univ, Coll Pharm, Incheon, South Korea.; Kim, I (corresponding author), Yonsei Univ, Yonsei Inst Pharmaceut Sci, Incheon, South Korea.; Kwon, HJ (corresponding author), Yonsei Univ, Chem Genom GRL, Dept Biotechnol, Seoul, South Korea.; Kim, SH (corresponding author), Korea Res Inst Chem Technol, Innovat Target Res Ctr, Therapeut & Biotechnol Div, Daejeon, South Korea.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde
A pyrrolo[1,2-a]pyrazine-based chemical territory was expanded via construction of new chemical library with distinctive substitution patterns, which was made possible by regiodivergent electrophilic acylation followed by aldol condensation. Biological screening of the compounds in this class revealed that the viability of human lymphoma U937 cells was strongly inhibited by 6b with a methoxy group at the o-position of the aromatic ring, but not by compounds 6t-w bearing a halogen at the o-position. Furthermore, 6x having a 2,4-dimethoxyphenyl group inhibited the survival of U937 cells more potently than 6b. In contrast, 6y possessing a 2,5-dimethoxyphenyl moiety did not show effective inhibition, implying the importance of orientation of the substituent(s) around the benzene ring. The anticancer action of 6x with safe therapeutic window could be associated with the FTase-p38 signaling axis.
About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Kim, J; Park, M; Choi, J; Singh, DK; Kwon, HJ; Kim, SH; Kim, I or concate me.. Category: isothiazole
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com