Quality Control of 2,5-Dimethoxybenzaldehyde. In 2020.0 J HETEROCYCLIC CHEM published article about RECEPTOR LIGANDS; INHIBITORS; DESIGN; BREAST; POTENT in [Metwally, Nadia H.; Ragab, Eman A.; Mohamed, Mona S.] Cairo Univ, Dept Chem, Fac Sci, Giza, Egypt in 2020.0, Cited 35.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.
Some novel N5-sulfonylated 4 were synthesized via sulfonylation of 5-amino-1H-pyrazole derivative 1 with arylsulfonyl chlorides. On the other hand, N1-alkylated pyrazoles 7 and 10 were synthesized through alkylation of compound 1 with each of chloroacetamides and ethylchloroacetate under different conditions. Condensation of compounds 4 and 7 with different aromatic aldehydes furnished the corresponding arylidene derivatives. In spite of, condensation of 10 with aromatic aldehydes afforded the 2-(5-amino-2-aryl-1H-pyrazol-1-yl)acetic acid. The structure of the newly synthesized compounds was elucidated by elemental analyses and spectral data. Also, the suggested mechanisms for their formation were studied. Additionally, some selected new compounds were screened against antimicrobial activity. Compound 7c exhibited a higher activity against Candida albicans (inhibition zone diameter [IZD] = 31.3 +/- 0.6 mm) than the standard antibiotic Nystatin (IZD = 21 +/- 0.5 mm). Also, compound 7c showed minimum inhibitory concentration = 125 and 250 mu g/mL against Klebsiella pneumonia and Staphylococcus aureus, respectively. Molecular docking study also was carried out for compound 7c.
About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Metwally, NH; Ragab, EA; Mohamed, MS or concate me.. Quality Control of 2,5-Dimethoxybenzaldehyde
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com