Authors Li, ZZ; Xin, WX; Wang, Q; Zhu, MY; Zhou, HC in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about in [Li, Zezhong; Xin, Weixiang; Wang, Qing; Zhu, Mingyan; Zhou, Huchen] Shanghai Jiao Tong Univ, Sch Pharm, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China in 2021, Cited 17. Product Details of 99-04-7. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7
The protozoan parasite Trypanosoma brucei (T. brucei) causes human African trypanosomiasis (HAT), which is a fatal and neglected disease in the tropic areas, and new treatments are urgently needed. Leucyl-tRNA synthetase (LeuRS) is an attractive target for the development of antimicrobial agents. In this work, starting from the hit compound thiourea ZCL539, we designed and synthesized a series of amides as effective T. brucei LeuRS (TbLeuRS) synthetic site inhibitors. The most potent compounds 74 and 91 showed IC50 of 0.24 and 0.25 mM, which were about 700-fold more potent than the starting hit compound. The structure-activity relationship was also discussed. These compounds provided a new scaffold and lead compounds for further development of antitrypanosomal agents. (C) 2021 Elsevier Masson SAS. All rights reserved.
Product Details of 99-04-7. About 3-Methylbenzoic acid, If you have any questions, you can contact Li, ZZ; Xin, WX; Wang, Q; Zhu, MY; Zhou, HC or concate me.
Reference:
Isothiazole – Wikipedia,
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