An article Synthesis of some 5-arylidene-2-(4-acetamidophenylimino)-thiazolidin-4-one derivatives and exploring their breast anticancer activity WOS:000510027200001 published article about BIOLOGICAL EVALUATION; 1,3-THIAZOLIDIN-4-ONE DERIVATIVES; CYTOTOXIC ACTIVITY; AGENTS; IDENTIFICATION; 4-THIAZOLIDINONES; ANTIOXIDANT; INHIBITORS; DESIGN; CANCER in [Abumelha, Hana M. A.] Princess Nourah Bint Abdulrahman Univ, Fac Sci, Dept Chem, Riyadh 84428, Saudi Arabia; [Saeed, Ali] Mansoura Univ, Fac Sci, Dept Chem, Mansoura, Egypt in 2020.0, Cited 31.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. COA of Formula: C9H10O3
Ten 2-(4-acetamidophenylimino)-5-arylidenethiazolidin-4-one derivatives 6a-k were synthesized and evaluated for their anticancer activity against MCF-7 cell line (breast adenocarcinoma). The synthetic approach involves cyclocondensation of N,N ‘-bis(4-acetamidophenyl)-thiourea (3) with ethyl bromoacetate in ethanol and sodium acetate to furnish the 2-(4-acetamidophenylimino)-4-thiazolidinone derivative 4, which underwent Knoevenagel condensation reaction with some substituted aldehydes to afford the targeted 2-(4-acetamidophenylimino)-5-arylidenethiazolidin-4-ones 6a-k. The 4-chlorobenzylidene-thiazolidin-4-one compound 6h exhibited strong inhibitory effect on the growth of breast cancer cell with IC50 (58.33 +/- 1.74 mu M), very close to that of the reference drug doxorubicin (IC50 48.06 +/- 0.36 mu M).
About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Abumelha, HMA; Saeed, A or concate me.. COA of Formula: C9H10O3
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com