Recently I am researching about STEREOSELECTIVE ALDOL CONDENSATIONS; MALEIC-ANHYDRIDE SEGMENT; ABSOLUTE-CONFIGURATION; ADDITION-REACTIONS; REAGENTS; IMMUNOSUPPRESSANT; CHEMISTRY; KETONES; ESTERIFICATION; BIOSYNTHESIS, Saw an article supported by the CAPES-FAPESPFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [FAPESP 2012/11220-9, FAPESP 14/50249-8, 15/08541-6, CNPq 303154/2015-2, 573.564/2008-6, 158926/2014-5]; CNPq-FAPESPConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [FAPESP 14/50249-8, 15/08541-6, CNPq 303154/2015-2, 573.564/2008-6, 158926/2014-5]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: de Sant’Ana, DP; Rezende, CD; Campagne, JM; Dias, LC; de Figueiredo, RM. The CAS is 93-97-0. Through research, I have a further understanding and discovery of Benzoic anhydride. Formula: C14H10O3
The studies culminating in the synthesis of two large subunits of tautomycetin are described. The first one, fragment C1-C12 that has an anti-1,3-dimethyl system and a terminal diene unit, was accomplished in 10 linear steps in 7.4% overall yield. The second one, fragment C13-C25 which bears the sensitive anhydride framework and the majority of the stereogenic centers, was prepared in 13 linear steps (longest sequence) in 8% overall yield. Among the key transformations used, a regioselective epoxide opening, a Pd-catalyzed addition of terminal alkyne to acceptor alkyne, a Mukaiyama aldol reaction, a Yamaguchi esterification, and a homemade mild di-esterification can be cited. The chosen strategies allowed good yields, stereoselectivity, reproducibility, and scalability for several important intermediates.
Formula: C14H10O3. About Benzoic anhydride, If you have any questions, you can contact de Sant’Ana, DP; Rezende, CD; Campagne, JM; Dias, LC; de Figueiredo, RM or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com