Application In Synthesis of Benzoic anhydride. Zhuang, Z; Yu, JQ in [Zhuang, Zhe; Yu, Jin-Quan] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA published Pd(II)-Catalyzed Enantioselective gamma-C(sp(3))-H Functionalizations of Free Cyclopropylmethylamines in 2020, Cited 38. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0.
Prized for their ability to reliably forge stereocenters with precise regiocontrol from simple and abundant starting materials, substrate-directable enantioselective reactions are widely used in modern organic synthesis. As such, enantioselective C(sp(3))-H functionalization reactions directed by innate functional groups could provide new routes to introduce molecular complexity within the inert hydrocarbon moiety, but to date this approach has been met with little success. While free primary aliphatic amines are common, versatile intermediates in synthesis, they are traditionally unreactive in C(sp(3))-H activation reactions. Herein we report the Pd-catalyzed enantioselective C(sp(3))-H functionalization of free aliphatic amines (cyclopropylmethylamines) enabled by a chiral bidentate thioether ligand. This ligand’s privileged bidentate coordination mode and thioether motif favor the generation of the requisite mono(amine)-Pd(II) intermediate, thus enabling the enantioselective C-H activation of free amines. The resulting C-Pd(II) species could engage in either Pd(II)/Pd(IV) or Pd(II)/Pd(0) catalytic cycles, enabling access to a diverse range of products through (hetero)arylation, carbonylation, and olefination reactions. Consequently, this versatile reactivity offers medicinal chemists a general strategy to rapidly prepare and functionalize biologically relevant amines.
Application In Synthesis of Benzoic anhydride. About Benzoic anhydride, If you have any questions, you can contact Zhuang, Z; Yu, JQ or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com