Formula: C8H10O2. Recently I am researching about FORMAL SYNTHESIS; (+/-)-BRAZILIN; CONSTRUCTION; CYCLIZATION; CYCLOADDITION; CARBOCYCLES; BRAZILIN; ACCESS; SCOPE, Saw an article supported by the Thailand Research Fund (TRF)Thailand Research Fund (TRF) [BRG5980010, DBG6080007]; Mahidol University. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Lekky, A; Ruengsatra, T; Ruchirawat, S; Ploypradith, P. The CAS is 151-10-0. Through research, I have a further understanding and discovery of 1,3-Dimethoxybenzene
The diene methyl ethers or acetates, constructed from the Li-Br exchange/addition reactions of 2-vinylbenzaldehydes and 2-(but-3en-1-yl)bromoarenes followed by etherification or acetylation of the corresponding alcohols, smoothly underwent the ring-closing metathesis (RCM) by using Hoveyda-Grubbs II as a catalyst to provide the corresponding benzannulated (Z)-cyclononenes as single products in good yields (up to 75%). The ensuing one-pot acid-mediated transannular cyclization/nucleophilic addition at C7 furnished the corresponding tetrahydro-5H-benzo[c]fluorenes as single stereoisomers with the exclusive cis stereochemistry at the ring junction (C5-C6) and trans at the site of nucleophilic attack (C6-C7) on the three contiguous stereogenic centers in good to excellent yield (up to 94%). The developed strategy was general; the reaction conditions were compatible with hydride, azide, and electron-rich aromatics as nucleophiles. In addition, various methoxylated benzannulated cyclononene acetates could be employed as substrates. Thus, tetrahydro-5H-benzo[c]fluorenes could be prepared in four steps from appropriately substituted bromoarenes and benzaldehydes in good yields (up to 56%) with excellent stereo- and regio-control.
About 1,3-Dimethoxybenzene, If you have any questions, you can contact Lekky, A; Ruengsatra, T; Ruchirawat, S; Ploypradith, P or concate me.. Formula: C8H10O2
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com