Recommanded Product: 93-02-7. In 2020.0 J MOL STRUCT published article about ANTITUMOR-ACTIVITY; CELL-LINE; DERIVATIVES; ANTICANCER; PC3; INHIBITION; COMPLEXES; APOPTOSIS; DOCKING; NI(II) in [Gur, Mahmut] Kastamonu Univ, Dept Forest Ind Engn, Kastamonu, Turkey; [Yerlikaya, Serife; Baloglu, Mehmet Cengiz; Altunoglu, Yasemin Celik] Kastamonu Univ, Dept Genet & Bioengn, Kastamonu, Turkey; [Sener, Nesrin] Kastamonu Univ, Dept Chem, Kastamonu, Turkey; [Ozkinali, Sevil] Hitit Univ, Dept Chem, Corum, Turkey; [Baloglu, Mehmet Cengiz] Univ Florida, IFAS, Dept Agron, Gainesville, FL 32611 USA; [Gokce, Halil] Giresun Univ, Vocat Sch Hlth Serv, Giresun, Turkey; [Demir, Serkan] Giresun Univ, Dept Ind Engn, Giresun, Turkey; [Sener, Izzet] Kastamonu Univ, Dept Food Engn, Kastamonu, Turkey in 2020.0, Cited 69.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.
The 1,3,4-thiadiazole core has been mainly used as a pharmacological scaffold in medicinal chemistry. A series of Schiff bases derived from 5-substituted-1,3,4-thiadiazole-2-amine were designed and synthesized to investigate their biological activities. Structures of compounds were clarified with FTIR, H-1 NMR and elemental analysis. Due to the importance of this core in pharmacology, all these newly synthesized compounds were tested for different biological properties at the same time. Compound 3A ((E)-N-(2,5-dimethoxybenzylidene)-5-(4-methoxyquinolin-2-yl)-1,3,4-thiadiazol-2-amine) and compound 4A ((E)-N-(2,5-dimethoxybenzylidene)-5-(3-methylbenzofuran-2-yl)-1,3,4-thiadiazol-2-amine) possessed high DNA protective ability against oxidative Fenton mixture. Compound 1A ((E)-N-(2,5-dimethoxybenzylidene)-5-(benzo[b]thiophen-2-yl)-1,3,4-thiadiazol-2-amine) and compound 2B ((E)-2-((5-(1H-indol-2-yl)-1,3,4-thiadiazol-2-ylimino)methyl)-6-methoxyphenol) showed strong antimicrobial activity against S. epidermidis. The most effective compound was detected as compound 3A which exhibited cytotoxicity on both PC-3 and MDA-MB-231 cancer cell lines. The IC50 of this compound was calculated as 370.7 mu M and 505.1 mu M for MDA-MB-231 and PC-3 cells, respectively. Molecular docking studies were also performed to examine the understanding of the mechanism behind the anti-cancer and anti-bacterial properties. For further study, compound 3A has the potential for utilization with chemotherapy drugs to establish a more efficient therapy strategy with minimum cytotoxicity against cancer cells. (C) 2020 Elsevier B.V. All rights reserved.
Recommanded Product: 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Gur, M; Yerlikaya, S; Sener, N; Ozkinali, S; Baloglu, MC; Gokce, H; Altunoglu, YC; Demir, S; Sener, I or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com