Day: October 25, 2021

Recently I am researching about STANDARD MOLAR ENTHALPIES; NORMAL BOILING TEMPERATURE; VAPOR-PRESSURES; THERMODYNAMIC PROPERTIES; HEAT-CAPACITIES; THERMOCHEMICAL PROPERTIES; SUBLIMATION ENTHALPIES; PHASE-TRANSITIONS; ORGANIC-COMPOUNDS; SUBSTITUTED BENZENES, Saw an article supported by the Ministry of Science and Higher Education of the Russian Federation [0671-2020-0061]. Category: isothiazole. Published in ELSEVIER in AMSTERDAM ,Authors: Solomonov, BN; Yagofarov, MI. The CAS is 151-10-0. Through research, I have a further understanding and discovery of 1,3-Dimethoxybenzene

An approach for the calculation of the vaporization enthalpies of aromatic and heteroaromatic compounds at T = 298.15 K with accuracy competitive with experiment was proposed. The vaporization enthalpies may be calculated from the solution enthalpies of liquid and solvation enthalpies in benzene. The solution enthalpies of liquids were shown to be constant within a given type of aromatic compounds. For a set of 67 liquid and 41 solid aromatic and heteroaromatic compounds not capable of intermolecular hydrogen bonding, it was experimentally demonstrated that the solution enthalpies of liquids or supercooled liquids in benzene were equal to 1 +/- 1 kJ . mol(-1). The way to consider intermolecular hydrogen bonding, e.g., in phenol, aniline, pyrrole derivatives, was also proposed. The methods for solvation enthalpy calculation were proposed previously. The calculated and literature vaporization enthalpies values of 415 aromatic and heteroaromatic compounds were compared. Average absolute deviation amounted to 1.3 kJ . mol(-1). The proposed approach is especially valuable for calculation of the vaporization enthalpies of low-volatile compounds, including those solid at T = 298.15 K. (C) 2020 Elsevier B.V. All rights reserved.

About 1,3-Dimethoxybenzene, If you have any questions, you can contact Solomonov, BN; Yagofarov, MI or concate me.. Category: isothiazole

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Application In Synthesis of 3-Methylbenzoic acid. In 2019 ORG BIOMOL CHEM published article about ASYMMETRIC REDUCTION; CARBONYL REDUCTASE; DERIVATIVES; CONVERSION; ALCOHOLS in [Wang, Zexu; Li, Zhining; Huang, Zedu; Chen, Fener] Fudan Univ, Dept Chem, Engn Ctr Catalysis & Synth Chiral Mol, 220 Handan Rd, Shanghai 200433, Peoples R China; [Wang, Zexu; Li, Zhining; Huang, Zedu; Chen, Fener] Shanghai Engn Res Ctr Ind Asymmetr Catalysis Chir, 220 Handan Rd, Shanghai 200433, Peoples R China; [Wu, Xiaofan] Fuzhou Univ, Coll Chem Engn, 2 Xueyuan Rd, Fuzhou 350100, Fujian, Peoples R China in 2019, Cited 29. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

We report here the stereoselective bioreduction of -nitro ketones catalyzed by ketoreductases (KREDs) with publicly known sequences. YGL039w and RasADH/SyADH were able to reduce 23 class I substrates (1-aryl-2-nitro-1-ethanone (1)) and ten class II substrates (1-aryloxy-3-nitro-2-propanone (4)) to furnish both enantiomers of the corresponding -nitro alcohols, with good-to-excellent conversions (up to >99%) and enantioselectivities (up to >99% ee) being achieved in most cases. To the best of our knowledge, KRED-mediated reduction of class II -nitro ketones (1-aryloxy-3-nitro-2-propanone (4)) is unprecedented. Select -nitro alcohols, including the synthetic intermediates of bioactive molecules (R)-tembamide, (S)-tembamide, (S)-moprolol, (S)-toliprolol and (S)-propanolol, were stereoselectively synthesized in preparative scale with 42% to 90% isolated yields, showcasing the practical potential of our developed system in organic synthesis. Finally, the advantage of using KREDs with known sequence was demonstrated by whole-cell catalysis, in which -nitro alcohol (R)-2k, the key synthetic intermediate of hypoglycemic natural product (R)-tembamide, was produced in a space-time yield of 178 g L-1 d(-1) as well as 95% ee by employing the whole cells of a recombinant E. coli strain coexpressing RasADH and glucose dehydrogenase as the biocatalyst.

Application In Synthesis of 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Wang, ZX; Wu, XF; Li, ZN; Huang, ZD; Chen, F or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recommanded Product: 385-00-2. Singh, AS; Agrahari, AK; Mishra, N; Singh, M; Tiwari, VK in [Singh, Anoop S.; Agrahari, Anand K.; Mishra, Nidhi; Singh, Mala; Tiwari, Vinod K.] Banaras Hindu Univ, Dept Chem, Inst Sci, Varanasi 221005, Uttar Pradesh, India published An Improved N-Acylation of 1 H -Benzotriazole Using 2,2-Dipyridyldisulfide and Triphenylphosphine in 2019, Cited 40. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2.

A novel path has been developed for the conversion of carboxylic acids into the corresponding N -acylbenzotriazoles by using 2,2-dipyridyl disulfide/PPh (3) in anhydrous dichloromethane in the presence of 1 H -benzotriazole. Mild reaction conditions, short reaction time, easy in handling, wide substrate scope, availability of reagents involved, and moreover avoiding the use of base makes this protocol quite useful for the laboratory practices for N -acylbenzotriazole synthesis.

About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Singh, AS; Agrahari, AK; Mishra, N; Singh, M; Tiwari, VK or concate me.. Recommanded Product: 385-00-2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Gandhi, SA; Barot, VM; Patel, MC; Malek, TJ; Patel, UH in [Gandhi, Sahaj A.] Bhavans Shri IL Pandya Arts Sci & Smt JM Shah Com, Dakor 388225, Gujarat, India; [Barot, V. M.; Patel, M. C.] Smt SM Panchal Sci Coll, PG Ctr Chem, Talod 383215, Gujarat, India; [Malek, T. J.] Kadi Sarva Vishwavidhayalay Univ, LDRP Inst Technol & Res, Gandhinagar 382024, Gujarat, India; [Patel, U. H.] Sardar Patel Univ, Dept Phys, Vallabh Vidyanagar 388120, Gujarat, India published MOLECULAR DOCKING, PHARMACOPHORE MODELLING AND 3D QSAR ANALYSIS OF NOVEL CHALCONE DERIVATIVES in 2019.0, Cited 18.0. Category: isothiazole. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

Chalcone based structures have many interesting biological properties like anti-malarial, anticancer, antiviral, antibacterial, antifungal, anti-hyperglycaemic and photo-cytotoxicity activities. In this study, the novel chalcone derivatives (1a-11) have been synthesized and investigated for antimicrobial activities. The MIC results of antimicrobial activities reveal that one of the chalcone derivative (2-Br- and 4OCH(3)- group) against specific bacteria are quite significant. 3D QSAR, three dimensional quantitative structure activity is one of the most powerful technique which involves the quantitative relationship between the biological activity of a set of compounds and their three dimensional structural properties, using statistical correlation methods. Pharmacophore modelling and molecular docking play an important role in drug design. To elucidate the relationship between structures and its activity, field-based 3D QSAR analysis has been carried out of novel chalcone derivatives. Structural properties such as electrostatic, hydrophobic, aromatic, and hydrogen-bond donor and acceptor have been worked out for novel chalcone derivatives. To investigate the influence of drugstore, chalcone derivatives (1a-11) have docked with receptor 210K and results displayed the highest Gscore of ligand If (3-OCH2C6H5-4-OCH3- group).

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Gandhi, SA; Barot, VM; Patel, MC; Malek, TJ; Patel, UH or concate me.. Category: isothiazole

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

SDS of cas: 93-97-0. I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Synthesis and evaluation of the HIF-1 alpha inhibitory activities of novel ursolic acid tetrazole derivatives published in 2019, Reprint Addresses Jin, XJ; Piao, HR (corresponding author), Yanbian Univ, Key Lab Nat Resources Changbai Mt & Funct Mol, Minist Educ, Coll Pharm, Yanji 133002, Peoples R China.. The CAS is 93-97-0. Through research, I have a further understanding and discovery of Benzoic anhydride.

The hypoxia-inducible factor-la (HIF-1 alpha) pathway has been implicated in tumor angiogenesis, growth, and metastasis. Therefore, the inhibition of this pathway is an important therapeutic target for the treatment of various types of cancers. Here, we designed and synthesized 31 ursolic acid (UA) derivatives containing a tetrazole moiety and evaluated them for their potential anti-tumor activities as HIF-la transcriptional inhibitors. Of these, compound 14d (IC50 0.8 +/- 0.2 mu M) displayed the most potent activity and compounds 14a (IC50 4.7 +/- 0.2 mu M) exhibited the most promising biological profile. Analysis of the structure-activity relationships of these compounds with HIF-1 alpha suggested that the presence of a tetrazole group located at C-28 of the UA derivatives was critical for their inhibitory activities.

SDS of cas: 93-97-0. About Benzoic anhydride, If you have any questions, you can contact Zhang, LH; Zhang, ZH; Li, MY; Wei, ZY; Jin, XJ; Piao, HR or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about CARBOXYLIC-ACID SALTS; CP-H BONDS; PRIMARY ALCOHOLS; UNACTIVATED C(SP(3))-H; AEROBIC OXIDATION; WATER; AMINES; ESTERIFICATION; ALKYLATION; CONVERSION, Saw an article supported by the DST of India [DST EMR/2015/000285]; UGC, IndiaUniversity Grants Commission, India; Indian Institute of Technology Delhi; DST-FISTDepartment of Science & Technology (India); IIT D. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Dolui, P; Hazra, S; Deb, M; Elias, AJ. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid. HPLC of Formula: C8H8O2

Picolinamide group assisted sp(3) C-H bond oxidation of methylene groups to the corresponding carbonyl compounds has been achieved by using simple bottle ferrocene as catalyst and Cu(OAc)(2) or tert-butyl peroxybenzoate (TBPB) as oxidant under mild conditions. This method is applicable for picolinamide bound organic as well as organometallic compounds with yields in the range of 46-82%. Control experiments and mechanistic studies indicate that a radical mechanism is responsible for these oxidative transformations in which ferrocene acts as a catalyst.

HPLC of Formula: C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Dolui, P; Hazra, S; Deb, M; Elias, AJ or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Palladium-catalyzed carbonylative synthesis of acylstannanes from aryl iodides and hexamethyldistannane WOS:000575167400014 published article about ACYL; KETONES; CARBOSTANNYLATION; ACYLSTANNYLATION; ALKYNES; SILYL; TIN in [Chen, Bo; Yuan, Yang; Xu, Jian-Xing; Wu, Xiao-Feng] Univ Rostock, Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany; [Franke, Robert] Evonik Ind AG, Paul Baumann Str 1, D-45772 Marl, Germany; [Franke, Robert] Ruhr Univ Bochum, Lehrstuhl Theoret Chem, Univ Str 150, D-44780 Bochum, Germany in 2020, Cited 21. Quality Control of 3-Methylbenzoic acid. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

In this communication, we describe a new method for the carbonylative synthesis of acylstannanes from aryl iodides and hexamethyldistannane. With Pd(PPh3)(4) as the catalyst and toluene as the solvent at 60 degrees C under 10 bar CO for 16 h, the desired acylstannanes were obtained in good to excellent yields. In order to facilitate isolation and analysis, the obtained acylstannanes were transformed into the corresponding benzoic acids by simply stirring under air for 5 h. (C) 2020 Elsevier B.V. All rights reserved.

Quality Control of 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Chen, B; Yuan, Y; Xu, JX; Franke, R; Wu, XF or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about C-H BOND; ANTRODIA-CAMPHORATA; SELECTIVE SYNTHESIS; MICHAEL ADDITION; CYCLIC IMIDES; DERIVATIVES; INDOLES; 1,4-ADDITION; CONSTRUCTION; ALKYLATION, Saw an article supported by the SERBDepartment of Science & Technology (India)Science Engineering Research Board (SERB), India [EMR/2017/000174]. Recommanded Product: 151-10-0. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Gairola, D; Peddinti, RK. The CAS is 151-10-0. Through research, I have a further understanding and discovery of 1,3-Dimethoxybenzene

Friedel-Crafts reaction is widely used for the C-C bond forming reaction to enable the direct connection of electron-rich arenes to electron-deficient olefins with high regioselectivity. Herein, a highly efficient, metal-free, and environmentally benign F-C strategy of electron-rich arenes with N-arylmaleimides has been developed for the construction of 3-arylsuccinimides in the presence of a green reagent methanesulfonic acid under mild reaction conditions. This highly facile and high-yielding protocol has compatibility with different electron-rich arenes.

Recommanded Product: 151-10-0. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Gairola, D; Peddinti, RK or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Solomonov, BN; Yagofarov, MI in ELSEVIER published article about STANDARD MOLAR ENTHALPIES; NORMAL BOILING TEMPERATURE; VAPOR-PRESSURES; THERMODYNAMIC PROPERTIES; HEAT-CAPACITIES; THERMOCHEMICAL PROPERTIES; SUBLIMATION ENTHALPIES; PHASE-TRANSITIONS; ORGANIC-COMPOUNDS; SUBSTITUTED BENZENES in [Solomonov, Boris N.; Yagofarov, Mikhail, I] Kazan Fed Univ, Dept Phys Chem, Kremlevskaya Str 18, Kazan 420008, Russia in 2020, Cited 186. HPLC of Formula: C8H10O2. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0

An approach for the calculation of the vaporization enthalpies of aromatic and heteroaromatic compounds at T = 298.15 K with accuracy competitive with experiment was proposed. The vaporization enthalpies may be calculated from the solution enthalpies of liquid and solvation enthalpies in benzene. The solution enthalpies of liquids were shown to be constant within a given type of aromatic compounds. For a set of 67 liquid and 41 solid aromatic and heteroaromatic compounds not capable of intermolecular hydrogen bonding, it was experimentally demonstrated that the solution enthalpies of liquids or supercooled liquids in benzene were equal to 1 +/- 1 kJ . mol(-1). The way to consider intermolecular hydrogen bonding, e.g., in phenol, aniline, pyrrole derivatives, was also proposed. The methods for solvation enthalpy calculation were proposed previously. The calculated and literature vaporization enthalpies values of 415 aromatic and heteroaromatic compounds were compared. Average absolute deviation amounted to 1.3 kJ . mol(-1). The proposed approach is especially valuable for calculation of the vaporization enthalpies of low-volatile compounds, including those solid at T = 298.15 K. (C) 2020 Elsevier B.V. All rights reserved.

About 1,3-Dimethoxybenzene, If you have any questions, you can contact Solomonov, BN; Yagofarov, MI or concate me.. HPLC of Formula: C8H10O2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Application In Synthesis of 2,5-Dimethoxybenzaldehyde. Bhutia, ZT; Das, D; Chatterjee, A; Banerjee, M in [Bhutia, Zigmee T.; Das, Dharmendra; Chatterjee, Amrita; Banerjee, Mainak] BITS Pilani, Dept Chem, KK Birla Goa Campus, Zuarinagar 403726, Goa, India published Efficient and Green Synthetic Route to Imidazo[1,2-a]pyridine by Cu(II)-Ascorbate-Catalyzed A(3)-Coupling in Aqueous Micellar Media in 2019.0, Cited 52.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

An efficient and environmentally sustainable method for the synthesis of imidazo[1,2-a]pyridine derivatives by domino A(3)-coupling reaction catalyzed by Cu(II)-ascorbate was developed in aqueous micellar media in the presence of sodium dodecyl sulfate (SDS). The catalyst, a dynamic combination of Cu(II)/Cu(I), was generated in situ in the reaction mixture by mixing CuSO4 with sodium ascorbate and aided a facile 5-exo-dig cycloisomerization of alkynes with the condensation products of 2-aminopyridines and aldehydes to afford a variety of imidazo[1,2-a]pyridines in good overall yields. A simple experimental setup, water as the green medium, and inexpensive catalyst and auxiliary are some of the merits of this protocol.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Bhutia, ZT; Das, D; Chatterjee, A; Banerjee, M or concate me.. Application In Synthesis of 2,5-Dimethoxybenzaldehyde

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com