I found the field of Pharmacology & Pharmacy very interesting. Saw the article Discovery and optimization of novel pyrazole-benzimidazole CPL304110, as a potent and selective inhibitor of fibroblast growth factor receptors FGFR (1-3) published in 2021. Safety of 1,3-Dimethoxybenzene, Reprint Addresses Yamani, A (corresponding author), Celon Pharma SA, Med Chem Dept, Mokra 41A, PL-05092 Kielpin, Lomianki, Poland.. The CAS is 151-10-0. Through research, I have a further understanding and discovery of 1,3-Dimethoxybenzene
The FGFR family is characterized by four receptors (FGFR 1-4), binding to 18 ligands called fibroblast growth factors (FGFs). Aberrant activation of FGFs and their FGFRs has been implicated in a broad spectrum of human tumors. We employed the scaffolds hybridization approach, scaffold-hopping concept to synthesize a series of novel pyrazole-benzimidazole derivatives 56 (a-x). Compound 56q (CPL304110) was identified as a selective and potent pan-FGFR inhibitor for FGFR1, -2, -3 with IC(50)s of 0.75 nM, 0.50 nM, 3.05 nM respectively, whereas IC50 of 87.90 nM for FGFR4. Due to its favorable pharmacokinetic profile, low toxicity and potent anti-tumor activity in vivo, compound 56q is currently under evaluation in phase I clinical trial for the treatment of bladder, gastric and squamous cell lung cancers (01FGFR2018; NCT04149691). (C) 2020 Elsevier Masson SAS. All rights reserved.
Safety of 1,3-Dimethoxybenzene. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Yamani, A; Zdzalik-Bielecka, D; Lipner, J; Stanczak, A; Piorkowska, N; Stanczak, PS; Olejkowska, P; Hucz-Kalitowska, J; Magdycz, M; Dzwonek, K; Dubiel, K; Lamparska-Przybysz, M; Popiel, D; Pieczykolan, J; Wieczorek, M or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com