I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Novel berberine-based derivatives with potent hypoglycemic activity published in 2019.0. Application In Synthesis of 2,5-Dimethoxybenzaldehyde, Reprint Addresses Tang, L (corresponding author), Guizhou Prov Engn Technol Res Ctr Chem Drug R&D, Guiyang 550004, Guizhou, Peoples R China.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde
Four series of berberine derivatives were designed and synthesized. All the synthetic compounds were screened for in vitro glucose consumption activity in HepG2 cell lines. The results showed that most of the tested compounds exhibited potent hypoglycemic activity, and the most potent compound 20b exhibited its potency by 3.23-fold of berberine, 1.39-fold of metformin and 1.20-fold of rosiglitazone, respectively. Western blot assay indicated these novel berberine-based derivatives executed their glucose-decreasing activity via the activation of AMPK pathway.
Application In Synthesis of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Wang, JT; Peng, JG; Zhang, JQ; Wang, ZX; Zhang, Y; Zhou, XR; Miao, J; Tang, L or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com