Name: 3-Methylbenzoic acid. In 2020 BIOORG MED CHEM LETT published article about SMALL-MOLECULE INHIBITOR; CARCINOMA IN-VITRO; ALPHA; DERIVATIVES; METABOLISM; ACTIVATOR; SIRTUINS; PATHWAY in [Dukanya; Metri, Prashant K.; Mohan, Surender; Basappa] Univ Mysore, Dept Studies Organ Chem, Lab Chem Biol, Mysore 570006, Karnataka, India; [Shanmugam, Muthu K.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117600, Singapore; [Rangappa, Shobith] Adichunchanagiri Inst Mol Med, Bg Nagara 571448, Nagamangalatalu, India; [Rangappa, Kanchugarakoppal S.] Univ Mysore, Dept Studies Chem, Mysore 570006, Karnataka, India in 2020, Cited 33. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.
A novel series of indazole tethered oxadiazoles (OTDs) derivatives were synthesized, characterized and screened for their anti-proliferative activity against hepatocellular carcinoma (HCC) cells. OTDs structure was further confirmed by Single-crystal X-ray diffraction studies. Among the tested OTDs, compound 2-(4-methoxyphenyl)-5-(1-methyl-1H-indazol-3-yl)-1,3,4 oxadiazole was found to inhibit the catalytical activity of SIRT2 and brings about apoptosis as shown by western blot analysis and flow cytometry data. Also, the tested OTDs were found to interact with the active site of human SIRT2 in silico but not with the cavity of co-crystal ligand 5-(3- hydroxypropyl)-3-(4-chlorophenyl)-1,2,4-oxadiazole, which indicate that these OTDs has potential in the development of SIRT2 inhibitors in liver cancer models.
About 3-Methylbenzoic acid, If you have any questions, you can contact Dukanya; Shanmugam, MK; Rangappa, S; Metri, PK; Mohan, S; Basappa; Rangappa, KS or concate me.. Name: 3-Methylbenzoic acid
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com