Safety of 2,6-Difluorobenzoic acid. In 2019 BIOORG MED CHEM LETT published article about MULTIDRUG-RESISTANCE; MOLECULAR-MECHANISMS; CANCER-CELLS; GLYCOPROTEIN; BIOAVAILABILITY; REVERSAL in [Guo, Yalan; Wang, Ke; Chen, Xiaoyu; Li, Haihong; Wan, Qi; Chen, Ying] Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai 201203, Peoples R China; [Morris-Natschke, Susan; Lee, Kuo-Hsiung] Univ N Carolina, Nat Prod Res Labs, UNC Eshelman Sch Pharm, Chapel Hill, NC 27599 USA; [Lee, Kuo-Hsiung] China Med Univ & Hosp, Chinese Med Res & Dev Ctr, Taichung, Taiwan; [Chen, Xiaoyu] Monash Univ, Fac Engn, Dept Mat Sci & Engn, Clayton, Vic 3800, Australia in 2019, Cited 13. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2.
Twenty-five seco-4-methyl-DCK derivatives were designed, synthesized and evaluated for chemoreversal activity when combined with paclitaxel or vincristine in two drug-resistant cancer cell lines (A2780/T and KB-V) respectively. Most of the new compounds displayed moderate to significant MDR reversal activities in the P-gp overexpressing A2780/T and KB-V cells. Especially, compounds 7o and 7y showed the most potent chemosensitization activities with more than 496 and 735 reversal ratios at a concentration of 10 mu M. Unexpectedly the newly synthesized compounds did not show chemosensitization activities observed in a non-P-gp overexpressing cisplatin resistant human ovarian cancer cell line (A2780/CDDP), implying that the MDR reversal effects might be associated with P-gp overexpression. Moreover, these compounds did not exhibit significant antiproliferative activities against nontumorigenic cell lines (HUVEC, HOSEC and T29) compared to the positive control verapamil at the tested concentration, which suggested better safety than verapamil. The pharmacological actions of the compounds will be studied further to explore their merit for development as novel candidates to overcome P-gp mediated MDR cancer.
Safety of 2,6-Difluorobenzoic acid. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Guo, YL; Wang, K; Chen, XY; Li, HH; Wan, Q; Morris-Natschke, S; Lee, KH; Chen, Y or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com