In 2019.0 EUR J MED CHEM published article about RESPONSE-SURFACE METHODOLOGY; KABACHNIK-FIELDS REACTION; ONE-POT SYNTHESIS; ANTITUMOR ACTIVITIES; PHOSPHONATE DERIVATIVES; PLATINUM(II) COMPLEXES; CELL BIOLOGY; CYTOTOXICITY; MECHANISM; TRIFLUOROMETHANESULFONATE in [Ewies, Ewies F.; El-Hussieny, Marwa; El-Sayed, Naglaa F.] Natl Res Ctr, Organometall & Organometalloid Chem Dept, 33 ElBohouth St, Giza 12622, Egypt; [Fouad, Marwa A.] Cairo Univ, Fac Pharm, Pharmaceut Chem Dept, Kasr El Aini St, Cairo 11562, Egypt in 2019.0, Cited 84.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Safety of 2,5-Dimethoxybenzaldehyde
alpha-aminophosphonate oxadiazoles (5a-m) were prepared in high yields by reacting of 1,3,4-oxadiazole acetohydrazide (3) with appropriate aldehydes and diethyl phosphite under Kabachnik-Fields conditions using Iron triflate as a catalyst. The reaction conditions were optimized using D-optimal experimental design. Possible reaction mechanisms were considered, and structures of the new products were based upon compatible elementary and spectroscopic evidence. In vitro antitumor activities of these compounds were evaluated against human cancer cell lines of colon (HCT116), breast (MCF7) and liver (HepG2) and compared with anticancer drug, Doxorubicin, employing standard MIT assay. Compounds 5i and 5l demonstrated good antiproliferative activities against HCT116 tumor cells comparable to doxorubicin with low cytotoxicity towards normal fetal colon cell (FHC). Additionally, their capacity to activate apoptosis cascade was studied in HCT116 cell line by investigating the activation of proteolytic caspases cascade, the levels of Cytochrome C, Bax and Bcl-2. Active caspase-3 level was enhanced by 6-8-folds in HCT116 cell line when stimulated with compounds 5i and 5l compared to the control. The level of Caspases 8 & 9 was also increased signifying that intrinsic and extrinsic pathways are both activated. They also induced Bax and down regulated Bcl-2 protein level in addition to over-expressing Cytochrome C level in HCT116 cell line. Also, HCT116 cell cycle was mainly arrested at the Pre-G1 and G2/M phases when treated with compounds 5i and 5l. (C) 2019 Elsevier Masson SAS. All rights reserved.
Safety of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Ewies, EF; El-Hussieny, M; El-Sayed, NF; Fouad, MA or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com