An article Stereoselective Convergent Synthesis of Tetrahydro-5H-benzo[c]fluorene via Nine-Membered Ring-Closing Metathesis and Transannular Acid-Mediated Cyclization/Nucleophilic Addition WOS:000467319600033 published article about FORMAL SYNTHESIS; (+/-)-BRAZILIN; CONSTRUCTION; CYCLIZATION; CYCLOADDITION; CARBOCYCLES; BRAZILIN; ACCESS; SCOPE in [Lekky, Anek; Ruengsatra, Tanachote; Ruchirawat, Somsak; Ploypradith, Poonsakdi] Chulabhorn Royal Acad, Chulabhorn Grad Inst, Program Chem Biol, 54 Kamphaeng Phet 6 Rd, Bangkok 10210, Thailand; [Ruchirawat, Somsak; Ploypradith, Poonsakdi] Chulabhorn Res Inst, Lab Med Chem, 54 Kamphaeng Phet 6 Rd, Bangkok 10210, Thailand; [Ruchirawat, Somsak; Ploypradith, Poonsakdi] Minist Educ, CHE, Ctr Excellence Environm Hlth & Toxicol, Bangkok 10400, Thailand in 2019, Cited 46. SDS of cas: 151-10-0. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0
The diene methyl ethers or acetates, constructed from the Li-Br exchange/addition reactions of 2-vinylbenzaldehydes and 2-(but-3en-1-yl)bromoarenes followed by etherification or acetylation of the corresponding alcohols, smoothly underwent the ring-closing metathesis (RCM) by using Hoveyda-Grubbs II as a catalyst to provide the corresponding benzannulated (Z)-cyclononenes as single products in good yields (up to 75%). The ensuing one-pot acid-mediated transannular cyclization/nucleophilic addition at C7 furnished the corresponding tetrahydro-5H-benzo[c]fluorenes as single stereoisomers with the exclusive cis stereochemistry at the ring junction (C5-C6) and trans at the site of nucleophilic attack (C6-C7) on the three contiguous stereogenic centers in good to excellent yield (up to 94%). The developed strategy was general; the reaction conditions were compatible with hydride, azide, and electron-rich aromatics as nucleophiles. In addition, various methoxylated benzannulated cyclononene acetates could be employed as substrates. Thus, tetrahydro-5H-benzo[c]fluorenes could be prepared in four steps from appropriately substituted bromoarenes and benzaldehydes in good yields (up to 56%) with excellent stereo- and regio-control.
SDS of cas: 151-10-0. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Lekky, A; Ruengsatra, T; Ruchirawat, S; Ploypradith, P or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com