I found the field of Chemistry very interesting. Saw the article An Indirect Strategy for Trifluoromethylation via an Iridium Catalyst: Approach to Generate Isocoumarin Skeletons in Bioactive Molecules published in 2020. Recommanded Product: 3-Methylbenzoic acid, Reprint Addresses Zhang, JY (corresponding author), Soochow Univ, Coll Energy, Soochow Inst Energy & Mat Innovat, Suzhou 215006, Peoples R China.; Zhao, YS (corresponding author), Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China.. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid
3-Bromo-1,1,1-trifluoroacetone was first disclosed as an effective indirect trifluoromethylation reagent to construct the important 3-trifluoromethyl isocoumarin skeleton. The reaction proceeds through a ligand-promoted, iridium-catalyzed ortho-selective C-H alkylation of benzoic acid and an intermolecular cyclization reaction promoted by silver acetate. A wide range of 3-trifluoromethyl isocoumarins can be easily obtained in moderate to good yields. Importantly, the isocoumarin skeleton can be easily formed in bioactive compounds, highlighting the importance of this reaction.
Recommanded Product: 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Zhou, KH; Geng, JY; Wang, DJ; Zhang, JY; Zhao, YS or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com