An article Continuous Flow Preparation of Enantiomerically Pure BINOL(s) by Acylative Kinetic Resolution WOS:000509518500001 published article about ENANTIOSELECTIVE SYNTHESIS; PHOSPHORUS LIGANDS; BRONSTED ACID; ALCOHOLS; ACTIVATION; BATCH; CATALYSIS; SECONDARY in [Lai, Junshan; Pericas, Miquel A.] Barcelona Inst Sci & Technol, Inst Chem Res Catalonia ICIQ, Av Paisos Catalans 16, Tarragona 43007, Spain; [Lai, Junshan] Univ Rovira & Virgili, Dept Quim Analit & Quim Organ, E-43007 Tarragona, Spain; [Neyyappadath, Rifahath M.; Smith, Andrew D.] Univ St Andrews, Sch Chem, EaStCHEM, St Andrews KY16 9ST, Fife, Scotland; [Pericas, Miquel A.] Univ Barcelona, Dept Quim Inorgan & Organ, E-08028 Barcelona, Spain in 2020, Cited 47. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0. Application In Synthesis of Benzoic anhydride
A polystyrene-immobilized isothiourea has been applied to the enantioselective acylative kinetic resolution (KR) of monoacylated BINOL(s) with inexpensive isobutyric anhydride in batch and flow. High selectivity values (s=29 at 0 degrees C) and a remarkable stability of the catalytic system in the operation conditions have been recorded for unsubstituted BINOL. No significant loss of activity/selectivity is recorded after 10 consecutive KR cycles in batch. A continuous flow process has been implemented and operated with a 100 mmol (32.8 g) sample of racemic monoacetylated BINOL in dichloromethane solution in an 84 hours experiment with a packed bed reactor containing 1 g (f=0.37 mmol.g(-1)) of the functional resin (s=17-21). Residence time can be decreased to 10 min with the same reactor to achieve a conversion of 58% with a selectivity factor s=17 when a more highly functionalized catalyst (f=0.88 mmol.g(-1)) is used. This translates into a remarkable combined productivity of 5.5 mmol(prod) . mmol(cat)(-1) . h(-1).
Application In Synthesis of Benzoic anhydride. About Benzoic anhydride, If you have any questions, you can contact Lai, JS; Neyyappadath, RM; Smith, AD; Pericas, MA or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com