Mohammadi-Khanaposhtani, M; Yahyavi, H; Barzegaric, E; Imanparast, S; Heravi, MM; Faramarzi, MA; Foroumadi, A; Adibi, H; Larijani, B; Mandavi, M in [Mohammadi-Khanaposhtani, Maryam] Babol Univ Med Sci, Cellular & Mol Biol Res Ctr, Hlth Res Inst, Babol, Iran; [Yahyavi, Hoda; Heravi, Majid M.] Alzahra Univ, Fac Chem & Phys, Dept Chem, Tehran, Iran; [Barzegaric, Ebrahim] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran; [Imanparast, Somaye; Faramarzi, Mohammad Ali] Univ Tehran Med Sci, Dept Pharmaceut Biotechnol, Fac Pharm, Tehran, Iran; [Imanparast, Somaye; Faramarzi, Mohammad Ali] Univ Tehran Med Sci, Biotechnol Res Ctr, Tehran, Iran; [Foroumadi, Alireza] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran, Iran; [Foroumadi, Alireza] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Tehran, Iran; [Adibi, Hossein; Larijani, Bagher; Mandavi, Mohammad] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran published New Biscoumarin Derivatives as Potent alpha-Glucosidase Inhibitors: Synthesis, Biological Evaluation, Kinetic Analysis, and Docking Study in 2020.0, Cited 26.0. HPLC of Formula: C9H10O3. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.
A new series of biscoumarin derivatives3a-nwere synthesized and evaluated for their alpha-glucosidase inhibitory activities. The reaction of the 4-aminocoumarin with benzaldehyde derivatives led to the formation of the title compounds in good yields. All the synthesized compounds showed potent alpha-glucosidase inhibitory activity with IC(50)ranging from 20.0 +/- 0.7 to180.1 +/- 0.8 mu M, in comparison with acarbose as the standard drug (IC50= 750.0 1.5 mu M). Among the synthesized compounds, 3,3′-(p-tolylmethylene)bis(4-amino-2H-chromen-2-one)3cwas found to be the most active compound with an IC(50)value of 20.0 +/- 0.7 mu M. Kinetic study exhibited that compound3cwas a competitive inhibitor against alpha-glucosidase (K-i= 22.4 mu M). In silico docking study for the most potent compound3cwas also performed.
HPLC of Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Mohammadi-Khanaposhtani, M; Yahyavi, H; Barzegaric, E; Imanparast, S; Heravi, MM; Faramarzi, MA; Foroumadi, A; Adibi, H; Larijani, B; Mandavi, M or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com