An article Discovery of a novel DNA binding agent via design and synthesis of new thiazole hybrids and fused 1,2,4-triazines as potential antitumor agents: Computational, spectrometric and in silico studies WOS:000479184600017 published article about BIOLOGICAL EVALUATION; ANTICANCER; DERIVATIVES; COMPLEXES; CYTOTOXICITY; COMPARE; LIGAND; PROBE; TOOL in [El-Wakil, Marwa H.; Ashour, Hayam M. A.; Khalil, Mounir A.; Ismail, Khadiga A.; Labouta, Ibrahim M.] Alexandria Univ, Fac Pharm, Dept Pharmaceut Chem, Alexandria 21521, Egypt; [El-Yazbi, Amira F.] Alexandria Univ, Fac Pharm, Dept Pharmaceut Analyt Chem, Alexandria 21521, Egypt in 2019.0, Cited 47.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Product Details of 93-02-7
New series of furan-thiazole hybrids (3a-f), thiazolo[2,3-c]-1,2,4-triazines (4a-f), their bioisosteres 1,3,4-thiadiazolo[2,3-c]-1,2,4-triazines (8a-d) and 1,2,4-triazino[4,3-b]-1,2,4-triazines (13a-e) were designed, synthesized and evaluated for their in vitro antitumor activities at the National Cancer Institute (NCI, USA). Among the synthesized compounds, 3d was found to exhibit promising broad spectrum antitumor activity (GI(50) MG-MID = 14.22 mu M) in a five-dose assay against the full panel NCI-cancer cell lines. 3d displayed higher antitumor activity against most tested cancer cell lines than 5-FU as reference. COMPARE analysis and molecular electrostatic potential computational study revealed that 3d probably exerts its antitumor properties through DNA binding similar to Clomesone. Further DNA binding studies using fluorescent terbium (Tb+3) probe revealed increased fluroresence of DNA-3d-Tb+3 mixture due to damage of the double-stranded DNA. Also, UV-vis absorption study was conducted which showed hyperchromic shift in DNA absorption confirming 3d-induced DNA damage. The assessed potency of 3d-induced DNA damage of calf thymus DNA showed a concentration as low as 2.04 ng/mL for a detectable DNA damage. Moreover, in silico calculation of physicochemical properties and druglikeness were in compliance to Lipinski’s rule.
Product Details of 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact El-Wakil, MH; El-Yazbi, AF; Ashour, HMA; Khalil, MA; Ismail, KA; Labouta, IM or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com