Application In Synthesis of 2,5-Dimethoxybenzaldehyde. West, MS; Mills, LR; McDonald, TR; Lee, JB; Ensan, D; Rousseaux, SAL in [West, Michael S.; Mills, L. Reginald; McDonald, Tyler R.; Lee, Jessica B.; Ensan, Deeba; Rousseaux, Sophie A. L.] Univ Toronto, Dept Chem, Davenport Res Labs, 80 St George St, Toronto, ON M5S 3H6, Canada; [Lee, Jessica B.] Paraza Pharma Inc, 275 Blvd Armand Frappier, Laval, PQ H7V 4A7, Canada; [Ensan, Deeba] Ontario Inst Canc Res, 661 Univ Ave Suite 510, Toronto, ON M5G 0A3, Canada published Synthesis of trans-2-Substituted Cyclopropylamines from alpha-Chloroaldehydes in 2019, Cited 48. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.
Cyclopropylamines are prevalent in pharmaceuticals and agrochemicals. Herein, we report the synthesis of trans-2-substituted cyclopropylamines in high diastereoselectivity from readily available alpha-chloroaldehydes. The reaction proceeds via trapping of an electrophilic zinc homoenolate with an amine followed by ring closure to generate the cyclopropylamine. We have also observed that cyclopropylamine cis/trans-isomerization occurs in the presence of zinc halide salts and that this process can be turned off by the addition of a polar aprotic cosolvent.
Application In Synthesis of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact West, MS; Mills, LR; McDonald, TR; Lee, JB; Ensan, D; Rousseaux, SAL or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com