Authors Ge, WZ; Hao, X; Han, FZ; Liu, ZQ; Wang, TP; Wang, MM; Chen, N; Ding, YH; Chen, Y; Zhang, Q in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about CINNAMIC ACID; SESQUITERPENE LACTONE; NAB-PACLITAXEL; ANTICANCER; INHIBITOR; DESIGN; CELLS; CHEMOTHERAPY; ANTIOXIDANT; APOPTOSIS in [Ge, Weizhi; Hao, Xin; Han, Fangzhi; Liu, Zhongquan; Wang, Tianpeng; Ding, Yahui; Chen, Yue; Zhang, Quan] Nankai Univ, State Key Lab Med Chem Biol, Coll Pharm, Haihe Educ Pk,38 Tongyan Rd, Tianjin 300353, Peoples R China; [Ge, Weizhi; Hao, Xin; Han, Fangzhi; Liu, Zhongquan; Wang, Tianpeng; Ding, Yahui; Chen, Yue; Zhang, Quan] Nankai Univ, Tianjin Key Lab Mol Drug Res, Haihe Educ Pk,38 Tongyan Rd, Tianjin 300353, Peoples R China; [Wang, Mengmeng; Chen, Ning] Accendatech Co Ltd, Tianjin 300384, Peoples R China in 2019.0, Cited 52.0. Product Details of 93-02-7. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7
Triple-negative breast cancer (TNBC) is the most aggressive cancers with a high recurrence rate and rapidly acquired drug resistance among various breast cancer subtypes. There is no specific drug for treatment of TNBC. Discovery of therapeutic agents with unique modes of actions is urgently needed. In this study, a series of seventy parthenolide derivatives was designed, synthesized, and evaluated for their anti-TNBC activities. Compound 7d exhibited the most potent activity against different breast cancer cells with IC50 values ranging from 0.20 mu M to 0.27 mu M, which demonstrated 11.6- to 18.6-fold improvement comparing to that of the parent compound parthenolide with IC50 values of 2.68-4.63 mu M. It is worth to note that 7d was more active than the positive control drug ADR. Moreover, compound 7d could induce apoptosis of SUM-159 cells through mitochondria pathway and cause G1 phase arrest of SUM-159 cells. These findings indicate that compound 7d deserves further studies as a lead compound for ultimate discovery of effective anti-TNBC drug. (C) 2019 Elsevier Masson SAS. All rights reserved.
Product Details of 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Ge, WZ; Hao, X; Han, FZ; Liu, ZQ; Wang, TP; Wang, MM; Chen, N; Ding, YH; Chen, Y; Zhang, Q or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com