Recently I am researching about ASYMMETRIC-SYNTHESIS; CONJUGATE ADDITION; ALDOL ADDITIONS; COMPLEXES; LACTONES; REGIOSELECTIVITY; SUBSTITUTION; MECHANISM; BOND, Saw an article supported by the NIH-NIGMSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [R01GM080269]; Caltech; Dow Next Generation Educator Fund; National Science FoundationNational Science Foundation (NSF). Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Jette, CI; Tong, ZJ; Hadt, RG; Stoltz, BM. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid. HPLC of Formula: C8H8O2
Herein, we report a Cu-catalyzed enantioselective allylic alkylation using a gamma-butyrolactone-derived silyl ketene acetal. Critical to the development of this work was the identification of a novel mono-picolinamide ligand with the appropriate steric and electronic properties to afford the desired products in high yield (up to 96 %) and high ee (up to 95 %). Aryl, aliphatic, and unsubstituted allylic chlorides bearing a broad range of functionality are well-tolerated. Spectroscopic studies reveal that a Cu-I species is likely the active catalyst, and DFT calculations suggest ligand sterics play an important role in determining Cu coordination and thus catalyst geometry.
About 3-Methylbenzoic acid, If you have any questions, you can contact Jette, CI; Tong, ZJ; Hadt, RG; Stoltz, BM or concate me.. HPLC of Formula: C8H8O2
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com