Day: October 13, 2021

An article Decarbonylative Sonogashira Cross-Coupling of Carboxylic Acids WOS:000664333200043 published article about CATALYZED HECK; ALKYNYLATION in [Liu, Chengwei; Szostak, Michal] Rutgers State Univ, Dept Chem, Newark, NJ 07102 USA in 2021, Cited 33. Computed Properties of C8H8O2. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

Decarbonylative Sonogashira cross-coupling of carboxylic acids by palladium catalysis is presented. The carboxylic acid is activated in situ by the formation of a mixed anhydride and further decarbonylates using the Pd(OAc)(2)/Xantphos system to provide an aryl-Pd intermediate, which is intercepted by alkynes to access the traditional Pd(0)/(II) cycle using carboxylic acids as ubiquitous and orthogonal electrophilic cross-coupling partners. The methodology efficiently constructs new C(sp(2))-C(sp) bonds and can be applied to the derivatization of pharmaceuticals. Mechanistic studies give support to decarbonylation preceding transmetalation in this process.

Computed Properties of C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Liu, CW; Szostak, M or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about LANOSTEROL 14-ALPHA-DEMETHYLASE; ANTIFUNGAL ACTIVITIES; BIOLOGICAL EVALUATION; CYTOTOXIC ALKALOIDS; DESIGN; SPONGE; EFFICIENT; EUDISTOMINS; TRYPTAMINE; ANTITUMOR, Saw an article supported by the Department of Chemistry, faculty of science, Silpakorn University; Department of Microbiology, faculty of science, Silpakorn University. Published in MDPI in BASEL ,Authors: Buaban, K; Phutdhawong, W; Taechowisan, T; Phutdhawong, WS. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde. Safety of 2,5-Dimethoxybenzaldehyde

A series of tetrahydro-ss-carbolines substituted with an alkyl or acyl side chain was synthesized and screened for its antifungal activity against plant pathogenic fungi (Bipolaris oryzae, Curvularia lunata, Fusarium semitectum, and Fusarium fujikuroi). The structure activity relationship revealed that the substituent at the piperidine nitrogen plays an important role for increasing antifungal activities. In this series, 2-octyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (3g) displayed potent antifungal activities with a minimum inhibitory concentration of 0.1 mu g/mL, including good inhibitory activity to the radial growth of fungus at a concentration of 100 mu g/mL compared to amphotericin B.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Buaban, K; Phutdhawong, W; Taechowisan, T; Phutdhawong, WS or concate me.. Safety of 2,5-Dimethoxybenzaldehyde

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Category: isothiazole. Authors Ojah, EO; Moronkola, DO; Ajiboye, CO; Yusuf, TL; Adeniyi-Akee, MA in TAYLOR & FRANCIS LTD published article about in [Ojah, Emmanuel Onah; Moronkola, Dorcas Olufunke; Ajiboye, Clement Odunayo] Univ Ibadan, Dept Chem, Ibadan, Nigeria; [Ojah, Emmanuel Onah] Mt Top Univ, Dept Chem Sci, Coll Basic & Appl Sci, Makogi Oba, Ogun State, Nigeria; [Yusuf, Tunde Lewis] Univ KwaZulu Natal, Sch Chem & Phys, Private Bag X54001,Westville Campus, ZA-4000 Durban, South Africa; [Adeniyi-Akee, Mukaram Akintunde] Igbined Univ, Dept Pharmaceut Chem, Coll Pharm, Okada, Edo State, Nigeria in 2021, Cited 47. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0

The chemical composition of essential oils (EOs) isolated by hydrodistillation from Pterocarpus soyauxii Taub. root wood and root bark were determined for the first time by GC/MS analysis. The EOs gave a percentage yield (w/w) of 0.34 % and 0.31 % for root wood and root bark respectively. A total of 60 compounds accounting for 86.1 % of the root wood EO composition were identified with monoterpenes (45.4 %) and sesquiterpenes (14.7 %) as predominant constituents. Root bark EO gave 53 identified constituents which make up about 78.5 % of the EO dominated by non-terpenes (23.4 %) and alkanes (14.1 %). The EOs are good sources of limonene (16.9 %), gamma-terpinene (9.8 %) and p-cymene (6.70 %). The anti-diabetic (alpha-amylase and alpha-glucosidase models) and antioxidant activities (DPPH and H2O2 models) of EOs were evaluated in comparison with standard drugs. Alpha-amylase inhibition gave IC50 values (mg/mL) of 0.0493 and 0.0471 for root wood and root bark EOs respectively, compared to acarbose the standard anti-diabetic drug (0.0401) while alpha-glucosidase assay gave IC50 values (mg/mL) of 0.0517 and 0.0486 for root wood and root bark EOs respectively, compared with acarbose (0.0418). In the DPPH antioxidant assay, root bark EO showed higher activity (0.157 mg/mL) compared to root wood EO (0.159 mg/mL) while Root wood and root bark EOs had IC(50 )values (mg/mL) of 0.157 and 0.171 respectively using the H2O2 model. Results revealed the presence of chemical constituents in the EOs which could be responsible for activities expressed by the plant.

Category: isothiazole. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Ojah, EO; Moronkola, DO; Ajiboye, CO; Yusuf, TL; Adeniyi-Akee, MA or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

In 2020 SYNTHESIS-STUTTGART published article about ASYMMETRIC 3+2 CYCLOADDITION; CHIRAL DIENE LIGANDS; H BOND ARYLATION; N-TOSYLAZIRIDINES; C-ARYLATION; N,N-DIALKYL-3-VINYLANILINES; DERIVATIVES; FUNCTIONALIZATION; TOSYLARYLIMINES; ALDEHYDES in [Kim, Yerin; Kwon, Yong Il; Kim, Sung-Gon] Kyonggi Univ, Dept Chem, 154-42 Gwanggyosan Ro, Suwon 16227, South Korea in 2020, Cited 57. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0. Formula: C8H10O2

A method for efficient and mild synthesis of diarylmethylamine scaffold, via Lewis acid catalyzed Friedel-Crafts reaction of donor-acceptor aziridines with N,N-dialkylanilines to afford a biologically important diarylmethylamine derivatives in high yields (up to 88%), is presented. This reaction is suitable for the synthesis of various diarylmethylamine derivatives and has a broad scope for electron-rich arenes, including dimethoxybenzene.

Formula: C8H10O2. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Kim, Y; Kwon, YI; Kim, SG or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Computed Properties of C7H4F2O2. Recently I am researching about SELECTIVE INHIBITORS; DISCOVERY; CATENIN; POTENT; GROWTH; CELLS; ASSAY; SITE, Saw an article supported by the Research Council of NorwayResearch Council of Norway [262613, 267639, 296226]; SouthEastern Norway Regional Health Authority [16/005289, 15/00779-2, 2015012, 2019090]; Norwegian Cancer SocietyNorwegian Cancer Society [5803958]; Jane and Aatos Erkko Foundation; Academy of FinlandAcademy of FinlandEuropean Commission [287063, 294085, 319299]; Sigrid Juselius FoundationSigrid Juselius Foundation. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Waaler, J; Leenders, RGG; Sowa, ST; Brinch, SA; Lycke, M; Nieczypor, P; Aertssen, S; Murthy, S; Galera-Prat, A; Damen, E; Wegert, A; Nazare, M; Lehtio, L; Krauss, S. The CAS is 385-00-2. Through research, I have a further understanding and discovery of 2,6-Difluorobenzoic acid

Tankyrases 1 and 2 are central biotargets in the WNT/beta-catenin signaling and Hippo signaling pathways. We have previously developed tankyrase inhibitors bearing a 1,2,4-triazole moiety and binding predominantly to the adenosine binding site of the tankyrase catalytic domain. Here we describe a systematic structure-guided lead optimization approach of these tankyrase inhibitors. The central 1,2,4-triazole template and trans-cyclobutyl linker of the lead compound 1 were left unchanged, while side-group East, West, and South moieties were altered by introducing different building blocks defined as point mutations. The systematic study provided a novel series of compounds reaching picomolar IC50 inhibition in WNT/beta-catenin signaling cellular reporter assay. The novel optimized lead 13 resolves previous atropisomerism, solubility, and Caco-2 efflux liabilities. 13 shows a favorable ADME profile, including improved Caco-2 permeability and oral bioavailability in mice, and exhibits antiproliferative efficacy in the colon cancer cell line COLO 320DM in vitro.

Computed Properties of C7H4F2O2. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Waaler, J; Leenders, RGG; Sowa, ST; Brinch, SA; Lycke, M; Nieczypor, P; Aertssen, S; Murthy, S; Galera-Prat, A; Damen, E; Wegert, A; Nazare, M; Lehtio, L; Krauss, S or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Jud, W; Maljuric, S; Kappe, CO; Cantillo, D in [Jud, Wolfgang; Maljuric, Snjezana; Kappe, C. Oliver; Cantillo, David] Karl Franzens Univ Graz, Inst Chem, NAWI Graz, Heinrichstr 28, A-8010 Graz, Austria; [Jud, Wolfgang; Maljuric, Snjezana; Kappe, C. Oliver; Cantillo, David] Res Ctr Pharmaceut Engn GmbH RCPE, Ctr Continuous Flow Synth & Proc CC FLOW, Inffeldgasse 13, A-8010 Graz, Austria published Cathodic C-H Trifluoromethylation of Arenes and Heteroarenes Enabled by an in Situ-Generated Triflyltriethylammonium Complex in 2019, Cited 46. HPLC of Formula: C8H10O2. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0.

While several trifluoromethylation reactions involving the electrochemical generation of CF3 radicals via anodic oxidation have been reported, the alternative cathodic, reductive radical generation has remained elusive. Herein, the first cathodic trifluoromethylation of arenes and heteroarenes is reported. The method is based on the electrochemical reduction of an unstable triflyltriethylammonium complex generated in situ from inexpensive triflyl chloride and triethylamine, which produces CF3 radicals that are trapped by the arenes on the cathode surface.

About 1,3-Dimethoxybenzene, If you have any questions, you can contact Jud, W; Maljuric, S; Kappe, CO; Cantillo, D or concate me.. HPLC of Formula: C8H10O2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Product Details of 93-02-7. In 2020.0 BIOORG MED CHEM LETT published article about QUINAZOLINE DERIVATIVES; ANTIBACTERIAL ACTIVITY; MOLECULAR DOCKING; ANTITUMOR; REARRANGEMENT; ANALOGS; SERIES; AGENTS in [Rasapalli, Sivappa; Murphy, Zachary F.; Sammeta, Vamshikrishna Reddy; Golen, James A.] Univ Massachusetts Dartmouth, Dept Chem & Biochem, 285 Old Westport Rd, N Dartmouth, MA 02747 USA; [Weig, Alexander W.; Melander, Roberta J.; Melander, Christian] Univ Notre Dame, Dept Chem & Biochem, 252A McCourtney Hall, Notre Dame, IN 46556 USA; [Macha, Prathyushakrishna; Vasudev, Milana C.] Univ Massachusetts Dartmouth, Dept Biomed Engn, 285 Old Westport Rd, N Dartmouth, MA 02747 USA in 2020.0, Cited 40.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

Synthesis of novel 4(3H)-quinazolinonyl aminopyrimidine derivatives has been achieved via quinazolinonyl enones which in turn were obtained from 2-acyl-4(3H)-quinazolinone. They have been assayed for biofilm inhibition against Gram-positive (methicillin-resistant Staphylococcus aureus (MRSA)) and Gram-negative bacteria (Acinetobacter baumannii). The analogues with 2,4,6-trimethoxy phenyl, 4-methylthio phenyl, and 3-bromo phenyl substituents (5h, 5j & 5k) have been shown to inhibit biofilm formation efficiently in MRSA with IC50 values of 20.7-22.4 mu M). The analogues 5h and 5j have demonstrated low toxicity in human cells in vitro and can be investigated further as leads.

Product Details of 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Rasapalli, S; Murphy, ZF; Sammeta, VR; Golen, JA; Weig, AW; Melander, RJ; Melander, C; Macha, P; Vasudev, MC or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Ligand Promoted, Palladium-Catalyzed C(sp(2))-H Arylation of Free Primary 2-Phenylethylamines WOS:000471212100075 published article about C-H BOND; PRIMARY AMINES; INTRAMOLECULAR AMINATION; OXIDATIVE CARBONYLATION; ALIPHATIC-AMINES; ACTIVATION; FUNCTIONALIZATION; C(SP(3))-H; BENZYLAMINES; ALKENYLATION in [Ding, Yongzheng; Chen, Xiaoxi; Gao, Yuzhen; Li, Shangda; Li, Gang] Chinese Acad Sci, Fujian Inst Res Struct Matter, Ctr Excellence Mol Synth, Key Lab Coal Ethylene Glycol & Its Related Techno, Fuzhou 350002, Fujian, Peoples R China; [Ding, Yongzheng; Chen, Xiaoxi; Li, Gang] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Fan, Shuai] Fuzhou Univ, Coll Chem, Fuzhou 350002, Fujian, Peoples R China in 2019, Cited 88. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0. Name: Benzoic anhydride

A mono-N-protected amino acid (MPAA) ligand promoted, Pd(II)-catalyzed C(sp(2))-H arylation of free primary 2-phenylethylamines using the native NH2 as the directing group has been achieved. This method is compatible with challenging simple primary 2-phenylethylamines bearing alpha-hydrogen atoms. Application of this protocol in the direct structure modification of the drug molecule amphetamine is also demonstrated.

About Benzoic anhydride, If you have any questions, you can contact Ding, YZ; Fan, S; Chen, XX; Gao, YZ; Li, SD; Li, G or concate me.. Name: Benzoic anhydride

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

I found the field of Pharmacology & Pharmacy very interesting. Saw the article A Novel Redox Modulator Induces a GPX4-Mediated Cell Death That Is Dependent on Iron and Reactive Oxygen Species published in 2020.0. SDS of cas: 93-02-7, Reprint Addresses Neamati, N (corresponding author), Univ Michigan, Coll Pharm, Dept Med Chem, Rogel Canc Ctr, Ann Arbor, MI 48109 USA.; Sechi, M (corresponding author), Univ Sassari, Dept Chem & Pharm, I-07100 Sassari, Italy.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

Redox modulators have been developed as an attractive approach to treat cancer. Herein, we report the synthesis, identification, and biological evaluation of a quinazolinedione reactive oxygen species (ROS) inducer, QD394, with significant cytotoxicity in pancreatic cancer cells. QD394 shows a transcriptomic profile remarkably similar to napabucasin, a cancer stemness inhibitor. Both small molecules inhibit STAT3 phosphorylation, increase cellular ROS, and decrease the GSH/GSSG ratio. Moreover, QD394 causes an iron- and ROS-dependent, GPX4 mediated cell death, suggesting ferroptosis as a major mechanism. Importantly, QD394 decreases the expression of LRPPRC and PNPT1, two proteins involved in mitochondrial RNA catabolic processes and both negatively correlated with the overall survival of pancreatic cancer patients. Pharmacokinetics-guided lead optimization resulted in the derivative QD394-Me, which showed improved plasma stability and reduced toxicity in mice compared to QD394. Overall, QD394 and QD394-Me represent novel ROS-inducing drug-like compounds warranting further development for the treatment of pancreatic cancer.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Hu, S; Sechi, M; Singh, PK; Dai, LP; McCann, S; Sun, DX; Ljungman, M; Neamati, N or concate me.. SDS of cas: 93-02-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Product Details of 93-02-7. Authors Moosavi-Zare, AR; Afshar-Hezarkhani, H; Rezaei, MM in TAYLOR & FRANCIS LTD published article about in [Moosavi-Zare, Ahmad R.; Afshar-Hezarkhani, Hadis; Rezaei, Mohammad M.] Sayyed Jamaleddin Asadabadi Univ, Dept Chem, Asadabad, Iran in 2020.0, Cited 32.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

Aqueous solution of boric acid, as an efficient and green catalytic system, was efficiently utilized tandem four-component condensation reaction of aryl aldehydes with ethyl acetoacetate, malononitrile, and hydrazine hydrate to give pyranopyrazole derivatives. By the reaction of boric acid with water, H+ was prepared and efficiently catalyzed the reaction under mild and green condition.

Product Details of 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Moosavi-Zare, AR; Afshar-Hezarkhani, H; Rezaei, MM or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com