Product Details of 93-02-7. In 2020.0 BIOORG MED CHEM LETT published article about QUINAZOLINE DERIVATIVES; ANTIBACTERIAL ACTIVITY; MOLECULAR DOCKING; ANTITUMOR; REARRANGEMENT; ANALOGS; SERIES; AGENTS in [Rasapalli, Sivappa; Murphy, Zachary F.; Sammeta, Vamshikrishna Reddy; Golen, James A.] Univ Massachusetts Dartmouth, Dept Chem & Biochem, 285 Old Westport Rd, N Dartmouth, MA 02747 USA; [Weig, Alexander W.; Melander, Roberta J.; Melander, Christian] Univ Notre Dame, Dept Chem & Biochem, 252A McCourtney Hall, Notre Dame, IN 46556 USA; [Macha, Prathyushakrishna; Vasudev, Milana C.] Univ Massachusetts Dartmouth, Dept Biomed Engn, 285 Old Westport Rd, N Dartmouth, MA 02747 USA in 2020.0, Cited 40.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.
Synthesis of novel 4(3H)-quinazolinonyl aminopyrimidine derivatives has been achieved via quinazolinonyl enones which in turn were obtained from 2-acyl-4(3H)-quinazolinone. They have been assayed for biofilm inhibition against Gram-positive (methicillin-resistant Staphylococcus aureus (MRSA)) and Gram-negative bacteria (Acinetobacter baumannii). The analogues with 2,4,6-trimethoxy phenyl, 4-methylthio phenyl, and 3-bromo phenyl substituents (5h, 5j & 5k) have been shown to inhibit biofilm formation efficiently in MRSA with IC50 values of 20.7-22.4 mu M). The analogues 5h and 5j have demonstrated low toxicity in human cells in vitro and can be investigated further as leads.
Product Details of 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Rasapalli, S; Murphy, ZF; Sammeta, VR; Golen, JA; Weig, AW; Melander, RJ; Melander, C; Macha, P; Vasudev, MC or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com