An article One-Step Enol Esterification of 1,3-Dicarbonyls with Carboxylic Acids Activated by Perfluoroalkanosulfonyl Fluoride WOS:000482666500026 published article about BECKMANN REARRANGEMENT; ALCOHOLS; CONCISE; ARYL in [Yan, Zhaohua; Wang, Yanmei; Jin, Hong’ai; Ai, Chengmei] Nanchang Univ, Coll Chem, Nanchang 330031, Jiangxi, Peoples R China; [Tian, Weisheng] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China in 2019, Cited 18. Formula: C8H8O2. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7
O-Acylation of 1,3-dicarbonyl compounds provides enol esters which act as precursors for the synthesis of chiral alcohols, natural products, heterocycles and functional materials. Perfluoroalkanosulfonyl fluoride (RfSO(2)F) is a class of excellent hydroxyl-activating reagent, and has been extensively developed and used in the formation of C-F, C-O, C-N and C-S bonds in organic synthesis. In this work one-step O-acylation of 1,3-dicarbonyl compounds (1,3-diketones and beta-ketonic esters) with carboxylic acids activated by RfSO2F in alkaline media was disclosed, and the corresponding O-acylation products (enol esters) were generated in moderate to good yields. The optimized reaction conditions are as follows: 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as base, CH2Cl2 as solvent, n-C4F9SO2F as activating reagent, room temperature for 30 min and the molar ratio of n(1,3-dicarbonyls): n(RCOOH): n(RfSO2F): n(DBU) being 1.0 : 1.0 : 1.0 : 4.0. A novel reagent for one-step O-acylation of 1,3-dicarbonyl compounds with carboxylic acids was developed. The application of RfSO2F in organic synthesis was further expanded.
Formula: C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Yan, ZH; Wang, YM; Jin, HA; Ai, CM; Tian, WS or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com