Quality Control of 2,5-Dimethoxybenzaldehyde. Lucescu, L; Ghinet, A; Shova, S; Magnez, R; Thuru, X; Farce, A; Rigo, B; Belei, D; Dubois, J; Bicu, E in [Lucescu, Liliana; Ghinet, Alina; Belei, Dalila; Bicu, Elena] AI I Cuza Univ Iasi, Fac Chem, Bd Carol I 11, Iasi 700506, Romania; [Ghinet, Alina; Farce, Amaury; Rigo, Benoit] Univ Lille, CHRU Lille, Fac Med Pole Rech, LIRIC,INSERM,U995, Lille, France; [Ghinet, Alina; Rigo, Benoit] UC Lille, Yncrea Hauts De France, Lab Chim Durable & Sante Hautes Etud Ingn HEI, Lille, France; [Shova, Sergiu] Petru Poni Inst Macromol Chem, Iasi, Romania; [Magnez, Romain; Thuru, Xavier] Univ Lille, UMR S 1172, JPARC, Ctr Rech Jean Pierre AUBERT Neurosci & Canc, Lille, France; [Farce, Amaury] Fac Sci Pharmaceut & Biol Lille, Lille, France; [Dubois, Joelle] CNRS, UPR2301, Inst Chim Subst Nat, Ctr Rech Gif, Gif Sur Yvette, France published Exploring isoxazoles and pyrrolidinones decorated with the 4,6-dimethoxy-1,3,5-triazine unit as human farnesyltransferase inhibitors in 2019.0, Cited 70.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.
Unprecedented triazinyl-isoxazoles were afforded via an effective cycloaddition reaction between nitrile oxides and the scarcely described 2-ethynyl-4,6-dimethoxy-1,3,5-triazine as dipolarophile. The biological evaluation of the newly synthesized compounds showed that the inhibition of human farnesyltransferase by zinc complexation could be improved with triazine-isoxazole moieties. The replacement of the isoxazole unit by a pyrrolidin-2-one was detrimental to the inhibitory activity while the pyrrolidin-2-thione derivatives conserved the biological potential. The potential of selected compounds to disrupt protein farnesylation in Chinese hamster ovary (CHO) cells transfected with pEGFP-CAAX was also evaluated.
About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Lucescu, L; Ghinet, A; Shova, S; Magnez, R; Thuru, X; Farce, A; Rigo, B; Belei, D; Dubois, J; Bicu, E or concate me.. Quality Control of 2,5-Dimethoxybenzaldehyde
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com