Wang, JT; Peng, JG; Zhang, JQ; Wang, ZX; Zhang, Y; Zhou, XR; Miao, J; Tang, L in [Wang, Jian-Ta; Peng, Jin-Gang; Zhang, Ji-Quan; Wang, Zhong-Xiao; Zhang, Yi; Miao, Jing; Tang, Lei] Guizhou Med Univ, Sch Pharm, State Key Lab Funct & Applicat Med Plants, Guiyang 550004, Guizhou, Peoples R China; [Wang, Jian-Ta] Guizhou Med Univ, Sch Basic Med Sci, Guiyang 550004, Guizhou, Peoples R China; [Zhou, Xun-Rong] Guizhou Chinese Tradit Med, Affiliated Hosp 2, Guiyang 550001, Guizhou, Peoples R China; [Wang, Jian-Ta; Zhang, Ji-Quan; Zhang, Yi; Tang, Lei] Guizhou Prov Engn Technol Res Ctr Chem Drug R&D, Guiyang 550004, Guizhou, Peoples R China published Novel berberine-based derivatives with potent hypoglycemic activity in 2019.0, Cited 25.0. HPLC of Formula: C9H10O3. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.
Four series of berberine derivatives were designed and synthesized. All the synthetic compounds were screened for in vitro glucose consumption activity in HepG2 cell lines. The results showed that most of the tested compounds exhibited potent hypoglycemic activity, and the most potent compound 20b exhibited its potency by 3.23-fold of berberine, 1.39-fold of metformin and 1.20-fold of rosiglitazone, respectively. Western blot assay indicated these novel berberine-based derivatives executed their glucose-decreasing activity via the activation of AMPK pathway.
HPLC of Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Wang, JT; Peng, JG; Zhang, JQ; Wang, ZX; Zhang, Y; Zhou, XR; Miao, J; Tang, L or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com