An article Design, synthesis and biological evaluation of novel c-Met/HDAC dual inhibitors WOS:000595004500007 published article about HISTONE DEACETYLASE INHIBITORS; 4-PHENOXYQUINOLINE DERIVATIVES; MULTITARGET THERAPEUTICS; MULTIPLE LIGANDS; CANCER; MET; POLYPHARMACOLOGY; RECEPTOR; MOIETY in [Dong, Yuhong; Hu, Hao; Sun, Yuwei; Qin, Mingze; Gong, Ping; Hou, Yunlei; Zhao, Yanfang] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, 103 Wenhua Rd, Shenyang 110016, Peoples R China in 2020, Cited 29. Safety of 3-Methylbenzoic acid. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7
In this work three novel series of c-Met/HDAC bifunctional inhibitors were designed and synthesized by merging pharmacophores of c-Met and HDAC inhibitors. The most potent compound 11j inhibited c-Met kinase and HDAC1 with IC50 values of 21.44 and 45.22 nM, respectively. In addition, 11j showed efficient antiproliferative activities against both MCF-7 and A549 cells with greater potency than the reference drug SAHA and Cabozantinib. This work may lay the foundation for developing novel dual c-Met/HDAC inhibitors as potential anticancer therapeutics.
About 3-Methylbenzoic acid, If you have any questions, you can contact Dong, YH; Hu, H; Sun, YW; Qin, MZ; Gong, P; Hou, YL; Zhao, YF or concate me.. Safety of 3-Methylbenzoic acid
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