An article Synthesis, Characterization, Molecular Docking, and Anticancer Evaluation of 4-Thiazolidinone Analogues WOS:000475943700009 published article about THIAZOLIDINONE DERIVATIVES; BIOLOGICAL EVALUATION; POTENTIAL ANTITUMOR; DRUG DISCOVERY; DESIGN; AGENTS; FLAVONOIDS; ASSAY in [Mushtaque, Md] Al Falah Univ, Sch Phys & Mol Sci, Dept Chem, Faridabad 121004, Haryana, India; [Avecilla, Fernando] Univ A Coruna, Fac Ciencias, Dept Quim, GrupoXenomar,CICA, Campus A Coruna, Coruna 15071 A, Spain; [Bin Hafeez, Zubair; Rizvi, Mohammad Moshahid A.] Jamia Millia Islamia, Dept Biosci, New Delhi 110025, India in 2019.0, Cited 41.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. HPLC of Formula: C9H10O3
Scaffolds containing one or more heteroatoms are ubiquitous in nature and are responsible for almost every biological processes in flora and fauna. The fact that heterocyclic cores have high propensity for biological targets, several nitrogen, oxygen, and sulfur-containing heterocyclic compounds have been reported in the last few decades. One such intriguing class is 4-thiazolidinone that exhibit diverse range of pharmacological activities. In the present study, we report synthesis, characterization, molecular docking, and anticancer evaluation of 10 new 4-thiazolidinone analogues (5-14). One of the compounds (11) was structurally characterized using single crystal X structure. Anticancer evaluation against hepatocellular carcinoma cell line (HepG2) revealed that compound (7) was the most potent (IC50=75 mu M) while other showed moderate to low activity (85-530 mu M). To underpin the druggability and possible modes of action, drug-likeness was determined and docking studies were carried out against beta-carbonic anhydrase receptor (PDB ID: 3IA). Attempts have also been made to establish a structure-activity relationship of the reported compounds.
About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Mushtaque, M; Avecilla, F; Bin Hafeez, Z; Rizvi, MMA or concate me.. HPLC of Formula: C9H10O3
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com