Day: October 8, 2021

Authors Song, ZL; Bai, FF; Zhang, BX; Fang, JG in AMER CHEMICAL SOC published article about CUL3-BASED E3 LIGASE; OXIDATIVE STRESS; THERAPEUTIC TARGET; PC12 CELLS; NEURODEGENERATIVE DISEASES; MITOCHONDRIAL DYSFUNCTION; KEAP1-NRF2-ARE PATHWAY; BIOLOGICAL EVALUATION; HYDROGEN-PEROXIDE; CANCER PREVENTION in [Song, Zi-Long; Bai, Feifei; Zhang, Baoxin; Fang, Jianguo] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Song, Zi-Long; Bai, Feifei; Zhang, Baoxin; Fang, Jianguo] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China in 2020, Cited 70. Category: isothiazole. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

Oxidative stress is implicated in the pathogenesis of a wide variety of neurodegenerative disorders, and accordingly, dietary supplement of exogenous antioxidants or/and upregulation of the endogenous antioxidant defense system are promising for therapeutic intervention or chemoprevention of neurodegenerative diseases. Nrf2, a master regulator of the cellular antioxidant machinery, cardinally participates in the transcription of cytoprotective genes against oxidative/electrophilic stresses. Herein, we report the synthesis of 59 structurally diverse dithiolethiones and evaluation of their neuroprotection against 6-hydroxydopamine- or H2O2 -induced oxidative damages in PC12 cells, a neuron-like rat pheochromocytoma cell line. Initial screening identified compounds 10 and 11 having low cytotoxicity but conferring remarkable protection on PC12 cells from oxidative-mediated damages. Further studies demonstrated that both compounds upregulated a battery of antioxidant genes as well as corresponding genes’ products. Significantly, silence of Nrf2 expression abolishes cytoprotection of 10 and 11, indicating targeting Nrf2 activation is pivotal for their cellular functions. Taken together, the two lead compounds discovered here with potent neuroprotective functions against oxidative stress via Nrf2 activation merit further development as therapeutic or chemopreventive candidates for neurodegenerative disorders.

About 3-Methylbenzoic acid, If you have any questions, you can contact Song, ZL; Bai, FF; Zhang, BX; Fang, JG or concate me.. Category: isothiazole

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Safety of 3-Methylbenzoic acid. Authors Zhou, JY; Liu, RQ; Wang, CY; Zhu, YM in AMER CHEMICAL SOC published article about in [Zhou, Jing-Ya; Liu, Rui-Qing; Wang, Cheng-Yi; Zhu, Yong-Ming] Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China in 2020, Cited 40. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

Transition metal-catalyzed cross-couplings have been widely employed in the synthesis of many important molecules in synthetic chemistry for the construction of diverse C-C bonds. Conventional cross-coupling reactions require active electrophilic coupling partners, such as organohalides or sulfonates, which are not environmentally friendly enough. Herein, we disclose the first nickel-catalyzed Suzuki-Miyaura cross-coupling of aryl anhydrides and arylboronic acids for the synthesis of biaryls in a decarbonylation manner. The reaction tolerates a wide range of electron-withdrawing, electron-neutral, and electron-donating substituents in this process.

About 3-Methylbenzoic acid, If you have any questions, you can contact Zhou, JY; Liu, RQ; Wang, CY; Zhu, YM or concate me.. Safety of 3-Methylbenzoic acid

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

I found the field of Chemistry very interesting. Saw the article Synthesis and Photochromism of Novel Pyridyl-Substituted Naphthopyrans published in 2020. Safety of 1,3-Dimethoxybenzene, Reprint Addresses de Azevedo, ODCC; Heron, BM (corresponding author), Univ Huddersfield, Sch Appl Sci, Dept Chem Sci, Huddersfield HD1 3DH, W Yorkshire, England.. The CAS is 151-10-0. Through research, I have a further understanding and discovery of 1,3-Dimethoxybenzene

Multitarget synthetic strategies to access novel photochromic 3H-naphtho[2,1-b]pyrans decorated with pyridyl units are described. The new pyridyl-substituted 3H-naphtho[2,1-b]pyrans display good photochromic properties with reversible generation of photomerocyanines, which exhibit mainly orange/red hues. Photochromic parameters including photocolorability and persistence of color vary tremendously on structural modification of the naphthopyran core.

About 1,3-Dimethoxybenzene, If you have any questions, you can contact de Azevedo, ODCC; Elliott, PIP; Gabbutt, CD; Heron, BM; Lord, KJ; Pullen, C or concate me.. Safety of 1,3-Dimethoxybenzene

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article A solid-supported arylboronic acid catalyst for direct amidation WOS:000462657900004 published article about AMIDE BOND FORMATION; CARBOXYLIC-ACIDS; ORGANIC-SYNTHESIS; FLOW; AMINES; CONVENIENT; REAGENTS; POLYMER in [Du, Yihao; Barber, Thomas; Lim, Sot Ee; Baxendale, Ian R.; Whiting, Andrew] Univ Durham, Sci Labs, Ctr Sustainable Chem Proc, Dept Chem, South Rd, Durham DH1 3QZ, England; [Rzepa, Henry S.] Imperial Coll, Dept Chem, South Kensington Campus, London SW7 2AZ, England in 2019, Cited 40. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Formula: C8H8O2

An efficient heterogeneous amidation catalyst has been prepared by co-polymerisation of styrene, DVB with 4-styreneboronic acid, which shows wide substrate applicability and higher reactivity than the equivalent homogeneous phenylboronic acid, suggesting potential cooperative catalytic effects. The catalyst can be easily recovered and reused; suitable for use in packed bed flow reactors.

About 3-Methylbenzoic acid, If you have any questions, you can contact Du, YH; Barber, T; Lim, SE; Rzepa, HS; Baxendale, IR; Whiting, A or concate me.. Formula: C8H8O2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Antioxidant and Cytotoxic Activities of Myrtaceae Essential Oils Rich in Terpenoids From Brazil WOS:000621046100001 published article about DIVERSITY; EUGENOL; GROWTH; LEAVES; PLANTS; WILD in [Jeronimo, Lucas Botelho] Univ Estado Para, Campus Barcarena, Barcarena, Brazil; [da Costa, Jamile S.] Univ Fed Para, Programa Posgrad Ciencias Farmaceut, Belem, Para, Brazil; [Pinto, Laine C.] Univ Fed Para, Hosp Univ Joao de Banos Barreto, Lab Neuropatol Expt, Belem, Para, Brazil; [Montenegro, Raquel C.] Univ Fed Ceara, Lab Farmacogenet, Fortaleza, Ceara, Brazil; [Setzer, William N.] Univ Alabama Huntsville, Dept Chem, Huntsville, AL 35899 USA; [Setzer, William N.; da Silva, Joyce Kelly R.] Aromat Plant Res Ctr, Lehi, UT USA; [Veras Mourao, Rosa Helena] Univ Fed Oeste Para, Lab Bioprospeccao & Biol Expt, Santarem, Brazil; [da Silva, Joyce Kelly R.] Univ Fed Para, Programa Posgrad Biotectiol, Belem, Para, Brazil; [Maia, Jose Guilherme S.] Univ Fed Maranhao, Programa Posgrad Quim, Sao Luis, Maranhao, Brazil; [Figueiredo, Pablo Luis B.] Univ Estado Para, Ctr Ciencias Sociais & Educ, Dept Ciencias Nat, Belem, Para, Brazil in 2021, Cited 43. Application In Synthesis of 1,3-Dimethoxybenzene. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0

This work analyzed the chemical compositions and evaluated the antioxidant and cytotoxic activities of essential oils (EO) of Eugenia patrisii (Epat), Eugenia stipitata (Esti), Myrcia splendens (Mspl), Myrcia sylvatica (Msyl), Psidium guajava (Pgua), and Psidium guineense (Pgui-1 and Pgui-2) from the Brazilian Amazon. Sesquiterpenoids were found in high concentrations in the oils of E. patrisii and M. splendens, which were rich in E-caryophyllene (32.0% and 45.8%); E. stipitata and M. sylvatica, which displayed germacrene D (11.8%) and germacrene B (24.5%); and P. guajava that showed epi-beta-bisabolol (16.1%) as the main compound. However, P. guineense samples (Pgui-1 and Pgui-2) were rich in monoterpenoids such as limonene (Pgui-1: 30.2%; Pgui-2 30.4%) and alpha-pinene (Pgui-1: 22.5%; Pgui-2: 17.7%). The samples showed a weak and moderate antioxidant activities in the DPPH assay, displaying inhibition rates from 11.5% to 38.6% (at 10 mg/mL). All samples were cytotoxic against human cancer cells by the MTT method. Epat oil showed higher activity against melanoma (SKMEL-19, IC(50)5.8 mu g/mL), gastric (AGP01, IC(50)3.2 mu g/mL), and colon (HCT116, IC(50)6.7 mu g/mL). Meanwhile, the samples Pgua and Pgui were more active against breast cancer cells (MCF7, IC(50)12.4 mu g/mL and 11.6 mu g/mL, respectively).

Application In Synthesis of 1,3-Dimethoxybenzene. About 1,3-Dimethoxybenzene, If you have any questions, you can contact Jeronimo, LB; da Costa, JS; Pinto, LC; Montenegro, RC; Setzer, WN; Mourao, RHV; da Silva, JKR; Maia, JGS; Figueiredo, PLB or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Category: isothiazole. In 2020 BIOORG CHEM published article about NATURAL-PRODUCT in [Xiao, Shengnan; Wang, Xude; Xu, Lei; Li, Tao; Cao, Jiaqing; Zhao, Yuqing] Shenyang Pharmaceut Univ, Sch Funct Food & Wine, Shenyang 110016, Peoples R China; [Zhao, Yuqing] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China in 2020, Cited 33. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

In this study, we introduced 1, 2, 4-triazole groups into panaxadiol (PD) to obtain 18 panaxadiol triazole derivatives. Five cancer cells and one normal cell were evaluated for cytotoxicity by MTT assay. The results showed that most of the derivatives could inhibit cancer cell proliferation, and the anti-proliferative activity of compound A1 was the most significant. For HepG-2 cells, the IC50 value was 4.21 +/- 0.54 mu M, which was nearly 15 times higher than the activity of PD. Further studies showed that compound A1 could induce apoptosis in HepG-2 cells, and could enhance the expression of Cl-caspase-3, Cl-caspase-9 and Cl-PARP. Moreover, Western blot analysis showed that after treating HepG-2 cells with compound A1, the expression of p53 protein was increased and the ratio of Bax/Bcl-2 was gradually increased. The cytoplasmic Bax is then translocated to the mitochondria, causing the release of Cyt c protein. Therefore, the results indicate that compound A1 induces apoptosis through the mitochondrial pathway and can be used the potential to develop new anti-proliferative agents.

About 3-Methylbenzoic acid, If you have any questions, you can contact Xiao, SN; Wang, XD; Xu, L; Li, T; Cao, JQ; Zhao, YQ or concate me.. Category: isothiazole

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Name: Benzoic anhydride. I found the field of Chemistry very interesting. Saw the article 5 ‘-Morpholino modification of the sense strand of an siRNA makes it a more effective passenger published in 2019, Reprint Addresses Manoharan, M (corresponding author), Alnylam Pharmaceut, 300 Third St, Cambridge, MA 02142 USA.. The CAS is 93-97-0. Through research, I have a further understanding and discovery of Benzoic anhydride.

The 5-monophosphate group plays an important role in strand selection during gene silencing mediated by small-interfering RNA. We show that blocking of 5 phosphorylation of the sense strand by introducing a 5-morpholino modification improves antisense strand selection and RNAi activity. The 5-morpholino modification of the antisense strand triggers complete loss of activity.

Name: Benzoic anhydride. About Benzoic anhydride, If you have any questions, you can contact Kumar, P; Parmar, RG; Brown, CR; Willoughby, JLS; Foster, DJ; Babu, IR; Schofield, S; Jadhav, V; Charisse, K; Nair, JK; Rajeev, KG; Maier, MA; Egli, M; Manoharan, M or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

In 2019 ANGEW CHEM INT EDIT published article about TRANSITION-METAL CATALYSIS; NONCOVALENT INTERACTIONS; ARENES; LIGAND; ACTIVATION; HYDROFORMYLATION; CONSTRUCTION; HETEROARENES; INSIGHTS; PHENOLS in [Bai, Shao-Tao; Bheeter, Charles B.; Reek, Joost N. H.] Univ Amsterdam, Vant Hoff Inst Mol Sci HIMS, Supramol & Homogeneous Catalysis Grp, Sci Pk 904, NL-1098 XH Amsterdam, Netherlands in 2019, Cited 76. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Category: isothiazole

Reported is an iridium catalyst for ortho-selective C-H borylation of challenging secondary aromatic amide substrates, and the regioselectivity is controlled by hydrogen-bond interactions. The BAIPy-Ir catalyst forms three hydrogen bonds with the substrate during the crucial activation step, and allows ortho-C-H borylation with high selectivity. The catalyst displays unprecedented ortho selectivities for a wide variety of substrates that differ in electronic and steric properties, and the catalyst tolerates various functional groups. The regioselective C-H borylation catalyst is readily accessible and converts substrates on gram scale with high selectivity and conversion.

Category: isothiazole. About 3-Methylbenzoic acid, If you have any questions, you can contact Bai, ST; Bheeter, CB; Reek, JNH or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Design, synthesis and biological evaluation of (E)-5-styryl-1,2,4-oxadiazoles as anti-tubercular agents WOS:000464108100054 published article about DRUG-RESISTANT TUBERCULOSIS; TRANS-CINNAMIC ACID; PARALLEL SYNTHESIS; DERIVATIVES; INHIBITORS; DOCKING in [Upare, Abhay Atmaram; Gadekar, Pradip K.; Sivaramakrishnan, H.] Piramal Enterprises Ltd, Dept Proc Dev, Lighthall A Wing, Hiranandani Business PK, Sakivihar Rd, Mumbai 400072, Maharashtra, India; [Naik, Nishigandha] Haffkine Inst Training Res & Testing, Acharya Donde MargPorel, Mumbai 400012, Maharashtra, India; [Khedkar, Vijay M.] Shri Vile Parle Kelavani Mandars Inst Pharm, Dept Pharmaceut Chem, Mumbai Agra Natl Hwy, Dhule 424001, Maharashtra, India; [Sarkar, Dhiman; Choudhari, Amit] CSIR, Natl Chem Lab, Combi Chem Bio Resource Ctr, Div Organ Chem, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India; [Upare, Abhay Atmaram; Roopan, S. Mohana] Vellore Inst Technol, Sch Adv Sci, Dept Chem, Chem Heterocycles & Nat Prod Res Lab, Vellore 632014, Tamil Nadu, India in 2019.0, Cited 26.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Formula: C9H10O3

Cinnamic acid and its derivatives are known for anti-tubercular activity. The present study reports the synthesis of cinnamic acid derivatives via bioisosteric replacement of terminal carboxylic acid with oxadiazole. A series of cinnamic acid derivatives (styryl oxadiazoles) were designed and synthesized in good yields by reaction of substituted cinnamic acids (2, 15a-15s) with amidoximes. The synthesized styryl oxadiazoles were evaluated in vitro for anti-tubercular activity against Mycobacterium tuberculosis (Mtb) H37Ra strain. The structure-activity relationship (SAR) study has identified several compounds with mixed anti-tubercular profiles. The compound 32 displayed potent anti-tubercular activity (IC50= 0.045 mu g/mL). Molecular docking studies on mycobacterial enoyl-ACP reductase enzyme corroborated well with the experimental findings providing a platform for structure based hit-to-lead development.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Upare, AA; Gadekar, PK; Sivaramakrishnan, H; Naik, N; Khedkar, VM; Sarkar, D; Choudhari, A; Roopan, SM or concate me.. Formula: C9H10O3

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Application In Synthesis of 2,5-Dimethoxybenzaldehyde. Recently I am researching about DERIVATIVES; DESIGN, Saw an article supported by the Fujian Provincial Key Laboratory of Innovative Drug Target Research [FJ-YW-2019KF01]; K.C. Wong Magna Fund in Ningbo University; Ningbo 3315 Innovative Talents Program. Published in HINDAWI LTD in LONDON ,Authors: Zhao, SX; Cao, Y; Cui, ZZ; Zhang, JY; Pan, ZX; Hu, HY. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

A series of 2-arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides 5a-5o were synthesized and characterized. The synthesized compounds (5a-5o) were screenedin vitro against three breast cancer cell lines: SKBR3, MDA-MB-231, and MCF-7 cancer cell lines by the MTT assay. According to MTT results, compounds 5k and 5l showed better antiproliferative activities over MCF-7 cell lines with IC50 values of 8.50 and 12.51 mu M. Colony formation assay indicated 5k/5l treatment obviously inhibited the growth of MCF-7 cells and 5k/5l-induced cell cycle was arrested in the G2-M phase. Moreover, 5k/5l significantly increased the level of cleaved PARP and induced the apoptosis in MCF-7 cells. In addition, compared to Hela cells, MCF-7 cells were more sensitive to 5k/5l treatment.

Application In Synthesis of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Zhao, SX; Cao, Y; Cui, ZZ; Zhang, JY; Pan, ZX; Hu, HY or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com