Dai, ZH; Zhu, J; Wang, JH; Su, WB; Yang, FL; Zhou, QF in [Dai, Zonghao; Zhu, Jin; Wang, Jiahua; Su, Wenbo; Yang, Fulai; Zhou, Qingfa] China Pharmaceut Univ, Dept Organ Chem, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China published Phosphine-Catalyzed Chemoselective [4+3] Cycloaddition of Alminine Esters and beta ‘-acetoxy Allenoates for Divergent Synthesis of Azepines in 2020.0, Cited 96.0. Recommanded Product: 3-Methylbenzoic acid. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.
Text. A general method for the synthesis of structural diversity and complexity of azepines from aldimine esters and beta ‘-acetoxy allenoates is reported. Under phosphine catalysis, a [4+3] cycloaddition for the formation of 1,3-dihydro-2H-azepine-2,2,4-tricarboxylates was achieved with broad substrate scope under mild reactions. A switchable process was given and a variety of important 2,3-dihydrochromeno[4,3-b]azepin-6(1H)-ones were selectively formed when the reaction was performed in the presence of Cs2CO3 and PPh3, which involved an intramolecular ester group migration and subsequent lactonization of 1,3-dihydro-2H-azepine-2,2,4-tricarboxylates. Besides easy handle process, high synthetic value of resulting products, it is worth to note that this work showed the novel example of 1,5-ethoxycarbonyl migration.
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