Category: isothiazole. In 2020 BIOORG CHEM published article about NATURAL-PRODUCT in [Xiao, Shengnan; Wang, Xude; Xu, Lei; Li, Tao; Cao, Jiaqing; Zhao, Yuqing] Shenyang Pharmaceut Univ, Sch Funct Food & Wine, Shenyang 110016, Peoples R China; [Zhao, Yuqing] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China in 2020, Cited 33. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.
In this study, we introduced 1, 2, 4-triazole groups into panaxadiol (PD) to obtain 18 panaxadiol triazole derivatives. Five cancer cells and one normal cell were evaluated for cytotoxicity by MTT assay. The results showed that most of the derivatives could inhibit cancer cell proliferation, and the anti-proliferative activity of compound A1 was the most significant. For HepG-2 cells, the IC50 value was 4.21 +/- 0.54 mu M, which was nearly 15 times higher than the activity of PD. Further studies showed that compound A1 could induce apoptosis in HepG-2 cells, and could enhance the expression of Cl-caspase-3, Cl-caspase-9 and Cl-PARP. Moreover, Western blot analysis showed that after treating HepG-2 cells with compound A1, the expression of p53 protein was increased and the ratio of Bax/Bcl-2 was gradually increased. The cytoplasmic Bax is then translocated to the mitochondria, causing the release of Cyt c protein. Therefore, the results indicate that compound A1 induces apoptosis through the mitochondrial pathway and can be used the potential to develop new anti-proliferative agents.
About 3-Methylbenzoic acid, If you have any questions, you can contact Xiao, SN; Wang, XD; Xu, L; Li, T; Cao, JQ; Zhao, YQ or concate me.. Category: isothiazole
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com