Application In Synthesis of 2,5-Dimethoxybenzaldehyde. Recently I am researching about DERIVATIVES; DESIGN, Saw an article supported by the Fujian Provincial Key Laboratory of Innovative Drug Target Research [FJ-YW-2019KF01]; K.C. Wong Magna Fund in Ningbo University; Ningbo 3315 Innovative Talents Program. Published in HINDAWI LTD in LONDON ,Authors: Zhao, SX; Cao, Y; Cui, ZZ; Zhang, JY; Pan, ZX; Hu, HY. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde
A series of 2-arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides 5a-5o were synthesized and characterized. The synthesized compounds (5a-5o) were screenedin vitro against three breast cancer cell lines: SKBR3, MDA-MB-231, and MCF-7 cancer cell lines by the MTT assay. According to MTT results, compounds 5k and 5l showed better antiproliferative activities over MCF-7 cell lines with IC50 values of 8.50 and 12.51 mu M. Colony formation assay indicated 5k/5l treatment obviously inhibited the growth of MCF-7 cells and 5k/5l-induced cell cycle was arrested in the G2-M phase. Moreover, 5k/5l significantly increased the level of cleaved PARP and induced the apoptosis in MCF-7 cells. In addition, compared to Hela cells, MCF-7 cells were more sensitive to 5k/5l treatment.
Application In Synthesis of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Zhao, SX; Cao, Y; Cui, ZZ; Zhang, JY; Pan, ZX; Hu, HY or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com