Application In Synthesis of 2,5-Dimethoxybenzaldehyde. In 2020 J CHEM SCI published article about ANTIPROLIFERATIVE ACTIVITY in [Huynh, Thi-Kim-Chi; Nguyen, Thanh-Danh; Hoang, Thi-Kim-Dung] VAST, Inst Chem Technol, 01 Mac Dinh Chi Str,Dist 1, Ho Chi Minh City, Vietnam; [Huynh, Thi-Kim-Chi; Hoang, Thi-Kim-Dung] VAST, Grad Univ Sci & Technol, 18 Hoang Quoc Viet Str, Hanoi, Vietnam; [Nguyen, Thi-Hong-An] Ton Duc Thang Univ, 19 Nguyen Huu Tho Str,Dist 7, Ho Chi Minh City, Vietnam; [Tran, Ngoc-Hoang-Son] Ho Chi Minh City Univ Technol, 268 Ly Thuong Kiet Str,Dist 10, Ho Chi Minh City, Vietnam in 2020, Cited 20. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.
This study reports a simple process to synthesize and separate of 2-(substituted-phenyl) benzimidazole derivatives with high yield and efficiency. Specifically, by reacting ortho-phenylenediamines with benzaldehydes using sodium metabisulphite as an oxidation agent in a mixture of solvent under mild condition, twenty-three compounds of benzimidazoles were obtained and separated easily using hexane and water to wash, respectively. The structure of all obtained compounds was identified by FTIR, NMR and HRMS. The SAR analysis of synthesized benzimidazoles on human lung (A549), breast (MDA-MB-231) and prostate (PC3) cancer cell lines showed that the presence of methyl group at 5(6)-position on benzimidazole scaffold was a contributing factor influencing the anticancer activity. The presence of electron-donating groups (OH, OMe, -NMe2, -O-CH2-C6H5) also caused significant increase of anticancer activity, while the presence of electron-withdrawing groups (-NO2, -CF3) on the phenyl group at 2-position of benzimidazole ring decreased the ability of inhibition of synthesized benzimidazoles. The compounds 2f and 2g displayed the significant anticancer activity on both A549 and PC3 cell lines.
About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Huynh, TKC; Nguyen, THA; Tran, NHS; Nguyen, TD; Hoang, TKD or concate me.. Application In Synthesis of 2,5-Dimethoxybenzaldehyde
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com