Category: isothiazole. Zhang, H; Zhang, RH; Liao, XM; Yang, D; Wang, YC; Zhao, YL; Xu, GB; Liu, CH; Li, YJ; Liao, SG; Zhou, M in [Zhang, Hong; Zhang, Rong-Hong; Liu, Chun-Hua; Li, Yong-Jun; Zhou, Meng] Guizhou Med Univ, Engn Res Ctr Dev & Applicat Ethn Med & TCM, State Key Lab Funct & Applicat Med Plants, Minist Educ, Guiyang 550004, Peoples R China; [Zhang, Hong; Liao, Xiang-Ming; Yang, Dan; Wang, Yu-Chan; Zhao, Yong-Long; Xu, Guo-Bo; Liu, Chun-Hua; Li, Yong-Jun; Liao, Shang-Gao; Zhou, Meng] Guizhou Med Univ, Sch Pharm, Guian New Dist 550025, Guizhou, Peoples R China; [Zhang, Rong-Hong] Guizhou Med Univ, Ctr Tissue Engn & Stem Cell Res, Key Lab Regenerat Med Guizhou Prov, Guiyang 550004, Peoples R China published Discovery of beta-Carboline Derivatives as a Highly Potent Cardioprotectant against Myocardial Ischemia-Reperfusion Injury in 2021, Cited 57. The Name is Benzoic anhydride. Through research, I have a further understanding and discovery of 93-97-0.
Timely myocardial reperfusion salvages ischemic myocardium from infarction, whereas reperfusion itself induces cardiomyocyte death, which is called myocardial ischemia/reperfusion (MI/R) injury. Herein, beta-carboline derivative 17c was designed and synthesized with obvious myocardial protective activity for the first time. Pretreatment of 17c effectively protected the cardiomyocyte H9c2 cells from H2O2-induced lactate dehydrogenase leakage and restored the endogenous antioxidants, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Besides, 17c effectively protected the mitochondria through decreasing the reactive oxygen species overproduction and enhancing the mitochondrial membrane potential. As a result, 17c significantly reduced the necrosis of cardiomyocytes in H2O2-induced oxidative stress, which was more potent than polydatin. In MI/R injury rats, 17c pretreatment obviously increased the levels of SOD and GSH-Px and inhibited the apoptosis of cardiomyocytes. Through this way, the size of myocardial infarction was significantly reduced after MI/R injury in vivo, better than that of polydatin, suggesting that 17c is a promising cardioprotectant for the prevention of MI/R injury.
Category: isothiazole. About Benzoic anhydride, If you have any questions, you can contact Zhang, H; Zhang, RH; Liao, XM; Yang, D; Wang, YC; Zhao, YL; Xu, GB; Liu, CH; Li, YJ; Liao, SG; Zhou, M or concate me.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com