Discovery of 3-Methylbenzoic acid

COA of Formula: C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Liu, CW; Szostak, M or concate me.

I found the field of Chemistry very interesting. Saw the article Decarbonylative Sonogashira Cross-Coupling of Carboxylic Acids published in 2021. COA of Formula: C8H8O2, Reprint Addresses Szostak, M (corresponding author), Rutgers State Univ, Dept Chem, Newark, NJ 07102 USA.. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid

Decarbonylative Sonogashira cross-coupling of carboxylic acids by palladium catalysis is presented. The carboxylic acid is activated in situ by the formation of a mixed anhydride and further decarbonylates using the Pd(OAc)(2)/Xantphos system to provide an aryl-Pd intermediate, which is intercepted by alkynes to access the traditional Pd(0)/(II) cycle using carboxylic acids as ubiquitous and orthogonal electrophilic cross-coupling partners. The methodology efficiently constructs new C(sp(2))-C(sp) bonds and can be applied to the derivatization of pharmaceuticals. Mechanistic studies give support to decarbonylation preceding transmetalation in this process.

COA of Formula: C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Liu, CW; Szostak, M or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com