In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system. 495-40-9, Name is 1-Phenylbutan-1-one, SMILES is CCCC(C1=CC=CC=C1)=O, in an article , author is Hong, Jin Ri, once mentioned of 495-40-9, HPLC of Formula: https://www.ambeed.com/products/495-40-9.html.
A novel series of fused-benzensulfonamide 2-N-(pyrazol-3-yl)methylbenzoldlisothiazole-1,1-dioxide derivatives was designed and synthesized as metabolically stable T-type calcium channel inhibitors. Several compounds, 9, 10, and 17, displayed potent T-type channel inhibitory activity. Among them, compounds 10 and 17 showed good metabolic stability in human liver microsomes, and low hERG channel and CYP450 inhibition. Compound 10 exhibited diabetic neuropathic pain-alleviating effects in a streptozotocin-induced peripheral diabetic neuropathy (PDN) model. The maximum efficacy of compound 10, which was 3-fold more potent than gabapentin, was observed at 1 h after administration, and co administration of compound 10 with gabapentin showed a considerable synergic effect. (C) 2017 Elsevier Ltd. All rights reserved.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com