New discoveries in chemical research and development in 2021, Chemistry involves the study of all things chemical – chemical processes, how they change and how they react in certain situations. 102-96-5, Name is (2-Nitrovinyl)benzene, SMILES is O=[N+](/C=C/C1=CC=CC=C1)[O-], in an article , author is Sipos, Attila, once mentioned of 102-96-5, SDS of cas: 102-96-5.
We have presented the synthesis of novel thiazolo-and isothiazolo-apomorphines 12-17 resulting-in part-from an unexpected isomerization step occurred during the acid-catalyzed rearrangement of precursor thiazolo-morphinandienes 3-5. These 2,3-disubstituted apomorphines represent a new group of A-ring substituted aporphines. The receptor binding studies revealed that with the exception of two derivatives all the tested compounds have limited affinity for dopamine-receptor subtypes. Functional calcium assay for the most active isothiazolo-apomorphine showed higher affinities for D-1 and D-2L subtypes. The docking of these ligands has been modelled to human D-2 and D-3 receptors. On the basis of the predicted models, we identified an important cation-p interaction for the binding of isothiazolo-apomorphine 16.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com