You could be based in a university, combining chemical research with teaching; working on developing and trialing new drugs; or helping to ensure national healthcare provision keeps pace with new discoveries. 1504-58-1, Name is 3-Phenylprop-2-yn-1-ol, molecular formula is C9H8O, belongs to isothiazole compound. In a document, author is Moon, Sanghun, introduce the new discover, Application In Synthesis of 3-Phenylprop-2-yn-1-ol.
A rhodium-catalyzed oxidative annulation of benzimidates with elemental sulfur for the direct construction of isothiazole rings is reported. The proposed reaction mechanism involving Rh(I)/Rh(III) redox is supported by a stoichiometric reaction of metallacycle species as well as DFT calculations. This method is also applicable to selenium cyclization to produce isoselenazole derivatives. The alkoxy substituent at C3 can be used for further functionalization of the azole core.
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.I hope my blog about 1504-58-1 is helpful to your research. Application In Synthesis of 3-Phenylprop-2-yn-1-ol.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com