Product Details of 21834-92-4, When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. 21834-92-4, Name is 5-Methyl-2-phenylhex-2-enal, SMILES is CC(C)C/C=C(C1=CC=CC=C1)/C=O, belongs to isothiazole compound. In a article, author is Bollinger, Sean R., introduce new discover of the category.
This work describes the discovery and characterization of novel 6-(1H-pyrazolo[4,3-b]pyridin-3-yl)amino-benzo[d]isothiazole-3-carboxamides as mGlu(4) PAMs. This scaffold provides improved metabolic clearance and CYP1A2 profiles compared to previously discovered mGlu(4) PAMs. From this work, 27o (VU6001376) was identified as a potent (EC50 = 50.1 nM, 50.5% GluMax) and selective mGlu(4) PAM with an excellent rat DMPK profile (in vivo rat CLP, = 3.1 mL/min/kg, t(1/2) = 445 min, CYP1A2 IC50 > 30 mu M). Compound 270 was also active in reversing haloperidol induced catalepsy in a rodent preclinical model of Parkinson’s disease.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield. If you are hungry for even more, make sure to check my other article about 21834-92-4, Product Details of 21834-92-4.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com