You could be based in a university, combining chemical research with teaching; working on developing and trialing new drugs; or helping to ensure national healthcare provision keeps pace with new discoveries. 66-98-8, Name is [1,1′-Biphenyl]-4,4′-dicarbaldehyde, molecular formula is C14H10O2, belongs to isothiazole compound. In a document, author is El Abdellaoui, Hassan, introduce the new discover, Application In Synthesis of [1,1′-Biphenyl]-4,4′-dicarbaldehyde.
The development of potent, orally bioavailable, and selective series of 5-amino-3-hydroxy-N(1-hydroxypropane-2-yl)isothiazole-4-carboxamidine inhibitors of MEK1 and MEK-2 kinase is described. Optimization of the carboxamidine and the phenoxyanifine group led to the identification of 55 which gave good potency as in vitro MEK1 inhibitors, and good oral exposure in rat. (c) 2006 Elsevier Ltd. All rights reserved.
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 66-98-8. Application In Synthesis of [1,1′-Biphenyl]-4,4′-dicarbaldehyde.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com