Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. 127-63-9, Name is Sulfonyldibenzene, molecular formula is C12H10O2S, SDS of cas: 127-63-9, belongs to isothiazole compound, is a common compound. In a patnet, author is Lipnicka, Urszula, once mentioned the new application about 127-63-9.
Several new derivatives of 5-hydrazino-3-methyl-4-isothiazolecarboxylic ethyl esters were synthesized. Using 4-aminoacetophenone, the hydrazine group was transformed in position 5 in the hydrazone which reacted with the isocyanates, aldehydes and sugars. Thirteen newly synthesized compounds were tested for their ability to affects the immunological response in vitro in several rodent models. The immunoregulatory properties of the compounds were, differential and dose-dependent, The strongest activity was exhibited by 5-{N’-[1-4}-4-[3-(-methoxyphenyl)-ureido]-phenylethylidene]-hydrazino}-3-methyl-4-isothiazolecarboxylic acid ethyl ester (compound 3a). The compound strongly inhibited the secondary, humoral immune response to sheep erythrocytes and the proliferative response of mouse splenocytes to concanavalin A and pokeweed mitogen. The immunotropic activities of the new isothiazole derivatives and potential application of the compounds in therapy are discussed.
Keep reading other articles of 127-63-9! Don’t worry, you don’t need a PhD in chemistry to understand the explanations! SDS of cas: 127-63-9.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com