Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. 29679-58-1, Name is 2-(3-Phenoxyphenyl)propanoic acid, molecular formula is C15H14O3, Name: 2-(3-Phenoxyphenyl)propanoic acid, belongs to isothiazole compound, is a common compound. In a patnet, author is MALLERON, JL, once mentioned the new application about 29679-58-1.
A series of 2-(aminoalkyl)naphth[1,8-cd]isothiazole 1,1-dioxides was synthesized and examined in various receptor binding tests. Most compounds demonstrated high affinity for the 5-HT2 receptor with moderate to high selectivity. A member of this series, compound 24 (RP 62203), displays high 5-HT2 receptor affinity (K(i) = 0.26 nM), which is respectively more than 100 and 1000 times higher than its affinity for alpha-1 (K(i) = 38 nM) and D2 (K(i) > 1000 nM) receptors. This compound is a potent orally effective and long lasting 5-HT2 antagonist in the mescaline-induced head-twitches test in mice and rats.
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 29679-58-1. Name: 2-(3-Phenoxyphenyl)propanoic acid.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com