Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. 66-77-3, Name is 1-Naphthaldehyde, molecular formula is C11H8O, belongs to isothiazole compound. In a document, author is Dyachenko, Maksim S., introduce the new discover, Quality Control of 1-Naphthaldehyde.
The reactivity of the 4-amino-2,3-dihydro-1H-lambda 1(6)-isothiazole-1,1-dioxide (beta-amino-gamma-sultam) framework has not been studied sufficiently. Here we describe the chemical properties of this heterocyclic system toward electrophiles on spiranic and non-spiranic substrates. A variety of C-electrophiles (acetic anhydride, benzoyl chloride, DMFDMA, 4,4-dimethoxybutan-2-one) and heteroatom electrophiles (bromine, nitrosyl acetate) have been explored. Both the C-5 and 4-amino positions of the beta-amino-gamma-sultam system are able to undergo electrophilic reactions. Heteroatom electrophiles attack the C-5 position, whereas carbo-electrophiles affect the amino group. beta-Amino-gamma-sultams also were used as starting compounds for the synthesis of 6- or 7-substituted 1 lambda(6)-isothiazolo[4,5-b]pyridine-1,1-dioxides through condensation reaction and palladium-catalyzed oxidative coupling.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 66-77-3. Quality Control of 1-Naphthaldehyde.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com