Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 1975-51-5, Name is 2-Methyl-4-nitrobenzoic acid, molecular formula is C8H7NO4, belongs to isothiazole compound. In a document, author is Chen, Lai, introduce the new discover, Safety of 2-Methyl-4-nitrobenzoic acid.
A series of isothiazole, 1,2,3-thiadiazole, and thiazole-based cinnamamide morpholine derivatives were rationally designed, synthesized, characterized, and evaluated for their fungicidal activities. Bioassay indicated that a combination of 3,4-dichloroisothiazole active substructures with cinnamamide morpholine lead to significant improvement of in vivo antifungal activities of the target compounds; among them, compound Sa exhibited good fungicidal activity against Pseudoperonspera cubensis in vivo with an inhibition rate of 100% at 100 mu g/mL. A field experiment indicated that the difference of efficacy between 5a (75.9%) and dimethomorph (77.1%) at 37.5 g ai/667 m(2) was not significant; and 5a also exhibited good activity against Botrytis cinerea by triggering accumulation of PAL and NPR1 defense-related gene expression and the defense associated enzyme phenylalanine ammonia-lyase (PAL) expression on cucumber, rather than direct inhibition. These findings strongly supported that 3,4-dichloroisothiazole containing cinnamamide morpholine 5a not only showed good fungicidal activity against P. cubensis but also exhibited plant innate immunity stimulation activity as a promising fungicide candidate with both fungicidal activity and systemic acquired resistance.
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.I hope my blog about 1975-51-5 is helpful to your research. Safety of 2-Methyl-4-nitrobenzoic acid.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com