Category: isothiazole, Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, improving understanding of environmental issues, and development of new chemical products and materials. 92-91-1, Name is 1-([1,1′-Biphenyl]-4-yl)ethanone, SMILES is CC(C1=CC=C(C2=CC=CC=C2)C=C1)=O, belongs to isothiazole compound. In a article, author is Bunch, L, introduce new discover of the category.
Direct functionalization of the 3-oxygenated isothiazole heteroaromatic parental system has not yet been reported in the literature. Here, we report the first regioselective lithiation of the 5-position of 3-(benzyloxy)isothiazole (4) using LDA in diethyl ether. The versatility of the methodology was explored by quenching with a variety of electrophiles to give the desired products 7a,b,d-g in 54-68% yield. Only benzoylation aiming at the synthesis of 7c was unsuccessful. Furthermore, a highly convergent synthesis of thioibotenic acid (1), the sulfur analogue of the neurotoxic natural product ibotenic acid, was carried out.
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 92-91-1. Category: isothiazole.
Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com